4x0q: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Ternary complex of human DNA polymerase theta C-terminal domain binding ddGTP opposite dCMP==

~~The entry~~ 4x0q is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4x0q]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X0Q OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X0Q FirstGlance].

~~Authors~~: ~~Zahn~~, K.E., ~~Doublie~~, S.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=DG3:2-3-DIDEOXYGUANOSINE-5-TRIPHOSPHATE'>DG3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4x0p|4x0p]]</td></tr>

~~Description:~~

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x0q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x0q RCSB], [http://www.ebi.ac.uk/pdbsum/4x0q PDBsum]</td></tr>

[[Category: ~~Zahn, K.E~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DPOLQ_HUMAN DPOLQ_HUMAN]] Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.<ref>PMID:14576298</ref>

== References ==

__TOC__

</StructureSection>

[[Category: DNA-directed DNA polymerase]]

[[Category: Doublie, S]]

[[Category: Zahn, K E]]

[[Category: Dna polymerase]]

[[Category: Transferase-dna complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Ternary complex of human DNA polymerase theta C-terminal domain binding ddGTP opposite dCMP==
+<StructureSection load='4x0q' size='340' side='right' caption='[[4x0q]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
-The entry 4x0q is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4x0q]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X0Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X0Q FirstGlance]. <br>
-Authors: Zahn, K.E., Doublie, S.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DG3:2-3-DIDEOXYGUANOSINE-5-TRIPHOSPHATE'>DG3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x0p|4x0p]]</td></tr>
-Description:
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x0q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x0q RCSB], [http://www.ebi.ac.uk/pdbsum/4x0q PDBsum]</span></td></tr>
-[[Category: Zahn, K.E]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DPOLQ_HUMAN DPOLQ_HUMAN]] Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.<ref>PMID:14576298</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: DNA-directed DNA polymerase]]
 [[Category: Doublie, S]]
+[[Category: Zahn, K E]]
+[[Category: Dna polymerase]]
+[[Category: Transferase-dna complex]]