4x30: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution==

~~The entry~~ 4x30 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4x30]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X30 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X30 FirstGlance]. <br>

~~Authors~~: Qi, X.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=T44:3,5,3,5-TETRAIODO-L-THYRONINE'>T44</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x30 OCA], [http://pdbe.org/4x30 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x30 RCSB], [http://www.ebi.ac.uk/pdbsum/4x30 PDBsum]</span></td></tr>

~~Description~~: ~~Crystal structure~~ of ~~human Thyroxine~~-binding globulin ~~complexed with thyroine at 1~~.~~55 Angstrom resolution~~

</table>

[[~~Category~~: ~~Unreleased Structures~~]]

== Disease ==

[[http://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN]] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:[http://omim.org/entry/314200 314200]]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid.

== Function ==

[[http://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN]] Major thyroid hormone transport protein in serum.

__TOC__

</StructureSection>

[[Category: Qi, X]]

[[Category: Cation pi interaction]]

[[Category: Hormone release]]

[[Category: Serpin]]

[[Category: Tbg]]

[[Category: Thyroxine]]

[[Category: Thyroxine-binding globulin]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution==
+<StructureSection load='4x30' size='340' side='right' caption='[[4x30]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
-The entry 4x30 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4x30]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X30 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X30 FirstGlance]. <br>
-Authors: Qi, X.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=T44:3,5,3,5-TETRAIODO-L-THYRONINE'>T44</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x30 OCA], [http://pdbe.org/4x30 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x30 RCSB], [http://www.ebi.ac.uk/pdbsum/4x30 PDBsum]</span></td></tr>
-Description: Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution
+</table>
-[[Category: Unreleased Structures]]
+== Disease ==
+[[http://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN]] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:[http://omim.org/entry/314200 314200]]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid.
+== Function ==
+[[http://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN]] Major thyroid hormone transport protein in serum.
+__TOC__
+</StructureSection>
 [[Category: Qi, X]]
+[[Category: Cation pi interaction]]
+[[Category: Hormone release]]
+[[Category: Serpin]]
+[[Category: Tbg]]
+[[Category: Thyroxine]]
+[[Category: Thyroxine-binding globulin]]
+[[Category: Transport protein]]