4x5t: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==alpha 1 glycine receptor transmembrane structure fused to the extracellular domain of GLIC==

~~The entry~~ 4x5t is ~~ON HOLD until sometime in~~ the ~~future~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4x5t]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X5T FirstGlance]. <br>

~~Authors~~: ~~Sauguet L~~., ~~Corringer P~~.J., ~~Huon C~~., ~~Delarue M~~.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x5t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x5t RCSB], [http://www.ebi.ac.uk/pdbsum/4x5t PDBsum]</span></td></tr>

~~Description~~: ~~alpha 1 glycine receptor transmembrane structure fused to~~ the extracellular ~~domain~~ of ~~GLIC~~

</table>

[[Category: ~~Unreleased Structures~~]]

== Function ==

[[Category: Delarue M]]

[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>

[[Category: Sauguet L]]

== References ==

[[Category: ~~Huon C~~]]

[[Category: ~~Corringer P.J~~]]

__TOC__

</StructureSection>

[[Category: Corringer, P J]]

[[Category: Delarue, M]]

[[Category: Huon, C]]

[[Category: Sauguet, L]]

[[Category: Cys-loop]]

[[Category: Glycine receptor]]

[[Category: Receptor pentameric]]

[[Category: Signaling protein]]

[[Category: Transmembrane receptor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==alpha 1 glycine receptor transmembrane structure fused to the extracellular domain of GLIC==
+<StructureSection load='4x5t' size='340' side='right' caption='[[4x5t]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
-The entry 4x5t is ON HOLD  until sometime in the future
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4x5t]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X5T FirstGlance]. <br>
-Authors: Sauguet L., Corringer P.J., Huon C., Delarue M.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x5t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x5t RCSB], [http://www.ebi.ac.uk/pdbsum/4x5t PDBsum]</span></td></tr>
-Description: alpha 1 glycine receptor transmembrane structure fused to the extracellular domain of GLIC
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
-[[Category: Delarue M]]
+[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
-[[Category: Sauguet L]]
+== References ==
-[[Category: Huon C]]
+<references/>
-[[Category: Corringer P.J]]
+__TOC__
+</StructureSection>
+[[Category: Corringer, P J]]
+[[Category: Delarue, M]]
+[[Category: Huon, C]]
+[[Category: Sauguet, L]]
+[[Category: Cys-loop]]
+[[Category: Glycine receptor]]
+[[Category: Receptor pentameric]]
+[[Category: Signaling protein]]
+[[Category: Transmembrane receptor]]