4xcx: Difference between revisions
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''' | ==METHYLTRANSFERASE DOMAIN OF SMALL RNA 2'-O-METHYLTRANSFERASE== | ||
<StructureSection load='4xcx' size='340' side='right' caption='[[4xcx]], [[Resolution|resolution]] 2.84Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4xcx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XCX FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xcx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xcx RCSB], [http://www.ebi.ac.uk/pdbsum/4xcx PDBsum]</span></td></tr> | |||
</table> | |||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/HENMT_HUMAN HENMT_HUMAN]] Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | |||
[[Category: Brown, P J]] | |||
[[Category: Dong, A]] | [[Category: Dong, A]] | ||
[[Category: Edwards, A M]] | |||
[[Category: Li, Y]] | [[Category: Li, Y]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Walker, J R]] | |||
[[Category: Wernimont, A]] | [[Category: Wernimont, A]] | ||
[[Category: Wu, H]] | [[Category: Wu, H]] | ||
[[Category: | [[Category: Zeng, H]] | ||
[[Category: | [[Category: Methyltransferase]] | ||
[[Category: | [[Category: Sah]] | ||
[[Category: | [[Category: Sgc]] | ||
[[Category: | [[Category: Transferase]] | ||
Revision as of 13:49, 14 January 2015
METHYLTRANSFERASE DOMAIN OF SMALL RNA 2'-O-METHYLTRANSFERASE
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