244d: Difference between revisions
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|PDB= 244d |SIZE=350|CAPTION= <scene name='initialview01'>244d</scene>, resolution 1.200Å | |PDB= 244d |SIZE=350|CAPTION= <scene name='initialview01'>244d</scene>, resolution 1.200Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=244d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=244d OCA], [http://www.ebi.ac.uk/pdbsum/244d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=244d RCSB]</span> | |||
}} | }} | ||
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[[Category: Murchie, A I.H.]] | [[Category: Murchie, A I.H.]] | ||
[[Category: Norman, D G.]] | [[Category: Norman, D G.]] | ||
[[Category: parallel-stranded tetraplex]] | [[Category: parallel-stranded tetraplex]] | ||
[[Category: quadruple helix]] | [[Category: quadruple helix]] | ||
[[Category: unusual dna]] | [[Category: unusual dna]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:45:06 2008'' | ||
Revision as of 22:45, 30 March 2008
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| 244d, resolution 1.200Å | |||||||||||||
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| Ligands: | CA, DG, DT, NA | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX
Overview
Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.
About this Structure
244D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
The high-resolution crystal structure of a parallel-stranded guanine tetraplex., Laughlan G, Murchie AI, Norman DG, Moore MH, Moody PC, Lilley DM, Luisi B, Science. 1994 Jul 22;265(5171):520-4. PMID:8036494
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