4a92: Difference between revisions

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==Full-length HCV NS3-4A protease-helicase in complex with a macrocyclic protease inhibitor.==
==Full-length HCV NS3-4A protease-helicase in complex with a macrocyclic protease inhibitor.==
<StructureSection load='4a92' size='340' side='right' caption='[[4a92]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
<StructureSection load='4a92' size='340' side='right' caption='[[4a92]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4a92]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A92 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4a92]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hepc 9hepc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A92 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F9K:(1R,2R,2S,6S,24AS)-17-FLUORO-6-(1-METHYL-2-OXOPIPERIDINE-3-CARBOXAMIDO)-19,19-DIOXIDO-5,21,24-TRIOXO-2-VINYL-1,2,3,5,6,7,8,9,10,11,12,13,14,20,21,23,24,24A-OCTADECAHYDROSPIRO[BENZO[S]PYRROLO[2,1-G][1,2,5,8,18]THIATETRAAZACYCLOICOSINE-22,1-CYCLOPRO-2-CARBOXYLATEPAN]-2-YL+4-FLUOROISOINDOLINE'>F9K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F9K:(1R,2R,2S,6S,24AS)-17-FLUORO-6-(1-METHYL-2-OXOPIPERIDINE-3-CARBOXAMIDO)-19,19-DIOXIDO-5,21,24-TRIOXO-2-VINYL-1,2,3,5,6,7,8,9,10,11,12,13,14,20,21,23,24,24A-OCTADECAHYDROSPIRO[BENZO[S]PYRROLO[2,1-G][1,2,5,8,18]THIATETRAAZACYCLOICOSINE-22,1-CYCLOPRO-2-CARBOXYLATEPAN]-2-YL+4-FLUOROISOINDOLINE'>F9K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nhu|1nhu]], [[2i1r|2i1r]], [[2wcx|2wcx]], [[1jxp|1jxp]], [[1gx6|1gx6]], [[2jc1|2jc1]], [[8ohm|8ohm]], [[1c2p|1c2p]], [[1a1q|1a1q]], [[1cu1|1cu1]], [[1bt7|1bt7]], [[2jc0|2jc0]], [[2ax1|2ax1]], [[1ns3|1ns3]], [[2xwy|2xwy]], [[1csj|1csj]], [[2who|2who]], [[1nhv|1nhv]], [[2brl|2brl]], [[1gx5|1gx5]], [[2brk|2brk]], [[2ax0|2ax0]], [[2awz|2awz]], [[1quv|1quv]], [[1os5|1os5]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nhu|1nhu]], [[2i1r|2i1r]], [[2wcx|2wcx]], [[1jxp|1jxp]], [[1gx6|1gx6]], [[2jc1|2jc1]], [[8ohm|8ohm]], [[1c2p|1c2p]], [[1a1q|1a1q]], [[1cu1|1cu1]], [[1bt7|1bt7]], [[2jc0|2jc0]], [[2ax1|2ax1]], [[1ns3|1ns3]], [[2xwy|2xwy]], [[1csj|1csj]], [[2who|2who]], [[1nhv|1nhv]], [[2brl|2brl]], [[1gx5|1gx5]], [[2brk|2brk]], [[2ax0|2ax0]], [[2awz|2awz]], [[1quv|1quv]], [[1os5|1os5]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a92 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a92 RCSB], [http://www.ebi.ac.uk/pdbsum/4a92 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a92 OCA], [http://pdbe.org/4a92 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a92 RCSB], [http://www.ebi.ac.uk/pdbsum/4a92 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a92 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4a92" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hepatitis c virus]]
[[Category: Arcy, A D]]
[[Category: Arcy, A D]]
[[Category: Bodendorf, U]]
[[Category: Bodendorf, U]]
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