2cy9: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[2cy9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CY9 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CY9 FirstGlance].

<table><tr><td colspan='2'>[[2cy9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CY9 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CY9 FirstGlance].

</td></tr><tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cy9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cy9 RCSB], [http://www.ebi.ac.uk/pdbsum/2cy9 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cy9 TOPSAN]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cy9 OCA], [http://pdbe.org/2cy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cy9 RCSB], [http://www.ebi.ac.uk/pdbsum/2cy9 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cy9 TOPSAN]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/~~THEM2_MOUSE THEM2_MOUSE~~]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.<ref>PMID:19405909</ref> <ref>PMID:24072708</ref>

[[http://www.uniprot.org/uniprot/ACO13_MOUSE ACO13_MOUSE]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.<ref>PMID:19405909</ref> <ref>PMID:24072708</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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__TOC__

</StructureSection>

[[Category: ~~Mus musculus~~]]

[[Category: Lk3 transgenic mice]]

[[Category: Hosaka, T]]

[[Category: Kishishita, S]]

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 <StructureSection load='2cy9' size='340' side='right' caption='[[2cy9]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2cy9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CY9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2cy9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CY9 FirstGlance]. <br>
 </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cy9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cy9 RCSB], [http://www.ebi.ac.uk/pdbsum/2cy9 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cy9 TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cy9 OCA], [http://pdbe.org/2cy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cy9 RCSB], [http://www.ebi.ac.uk/pdbsum/2cy9 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cy9 TOPSAN]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/THEM2_MOUSE THEM2_MOUSE]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.<ref>PMID:19405909</ref> <ref>PMID:24072708</ref>
+[[http://www.uniprot.org/uniprot/ACO13_MOUSE ACO13_MOUSE]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.<ref>PMID:19405909</ref> <ref>PMID:24072708</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 22: / Line 22: @@
 __TOC__
 </StructureSection>
-[[Category: Mus musculus]]
+[[Category: Lk3 transgenic mice]]
 [[Category: Hosaka, T]]
 [[Category: Kishishita, S]]