2bt4: Difference between revisions
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|PDB= 2bt4 |SIZE=350|CAPTION= <scene name='initialview01'>2bt4</scene>, resolution 1.70Å | |PDB= 2bt4 |SIZE=350|CAPTION= <scene name='initialview01'>2bt4</scene>, resolution 1.70Å | ||
|SITE= <scene name='pdbsite=AC1:Trs+Binding+Site+For+Chain+L'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Trs+Binding+Site+For+Chain+L'>AC1</scene> | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=CA2:(1S,3R,4R,5S)-1,3,4-TRIHYDROXY-5-(3-PHENOXYPROPYL)CYCLOHEXANECARBOXYLIC+ACID'>CA2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene> | ||
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span> | |||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bt4 OCA], [http://www.ebi.ac.uk/pdbsum/2bt4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bt4 RCSB]</span> | |||
}} | }} | ||
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[[Category: Stewart, K A.]] | [[Category: Stewart, K A.]] | ||
[[Category: Toscano, M D.]] | [[Category: Toscano, M D.]] | ||
[[Category: amino-acid biosynthesis]] | [[Category: amino-acid biosynthesis]] | ||
[[Category: aromatic amino acid biosynthesis]] | [[Category: aromatic amino acid biosynthesis]] | ||
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[[Category: shikimate pathway]] | [[Category: shikimate pathway]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:11:20 2008'' | ||
Revision as of 23:11, 30 March 2008
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| 2bt4, resolution 1.70Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sites: | AC1 | ||||||||||||
| Ligands: | CA2, GOL, PO4, TRS | ||||||||||||
| Activity: | 3-dehydroquinate dehydratase, with EC number 4.2.1.10 | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
TYPE II DEHYDROQUINASE INHIBITOR COMPLEX
Overview
Selective inhibitors of type II dehydroquinase were rationally designed to explore a second binding-pocket in the active-site. The molecular modelling, synthesis, inhibition studies and crystal structure determination are described.
About this Structure
2BT4 is a Single protein structure of sequence from Streptomyces coelicolor. Full crystallographic information is available from OCA.
Reference
Rational design of new bifunctional inhibitors of type II dehydroquinase., Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2005 Sep 7;3(17):3102-4. Epub 2005 Aug 1. PMID:16106291
Page seeded by OCA on Mon Mar 31 02:11:20 2008
