2cc3: Difference between revisions
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|ACTIVITY= | |ACTIVITY= | ||
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cc3 OCA], [http://www.ebi.ac.uk/pdbsum/2cc3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cc3 RCSB]</span> | |||
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[[Category: Ward, D.]] | [[Category: Ward, D.]] | ||
[[Category: Zambryski, P C.]] | [[Category: Zambryski, P C.]] | ||
[[Category: agrobacterium]] | [[Category: agrobacterium]] | ||
[[Category: consurf]] | [[Category: consurf]] | ||
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[[Category: virb8]] | [[Category: virb8]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:19:24 2008'' | ||
Revision as of 23:19, 30 March 2008
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| 2cc3, resolution 2.20Å | |||||||||||||
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| Sites: | AC1 | ||||||||||||
| Ligands: | MPD | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
STRUCTURE OF AGROBACTERIUM TUMEFACIENS VIRB8 PROTEIN
Overview
Bacterial type IV secretion systems (T4SS) translocate DNA and/or proteins to recipient cells, thus providing a mechanism for conjugative transfer of genetic material and bacterial pathogenesis. Here we describe the first structure of a core component from the archetypal Agrobacterium tumefaciens T4SS: the 2.2-A resolution crystal structure of the VirB8 periplasmic domain (pVirB8(AT)). VirB8 forms a dimer in the crystal, and we identify residues likely important for stabilization of the dimer interface. Structural comparison of pVirB8(AT) with Brucella suis VirB8 confirms that the monomers have a similar fold. In addition, the pVirB8(AT) dimer superimposes very closely on the B. suis VirB8 dimer, supporting the proposal that dimer formation in the crystal reflects self-interactions that are biologically significant. The evolutionary conservation level for each residue was obtained from a data set of 84 VirB8 homologs and projected onto the protein structure to indicate conserved surface patches that likely contact other T4SS proteins.
About this Structure
2CC3 is a Single protein structure of sequence from Agrobacterium tumefaciens. Full crystallographic information is available from OCA.
Reference
Agrobacterium tumefaciens VirB8 structure reveals potential protein-protein interaction sites., Bailey S, Ward D, Middleton R, Grossmann JG, Zambryski PC, Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2582-7. Epub 2006 Feb 15. PMID:16481621
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