2cky: Difference between revisions
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|PDB= 2cky |SIZE=350|CAPTION= <scene name='initialview01'>2cky</scene>, resolution 2.90Å | |PDB= 2cky |SIZE=350|CAPTION= <scene name='initialview01'>2cky</scene>, resolution 2.90Å | ||
|SITE= <scene name='pdbsite=AC1:Tpp+Binding+Site+For+Chain+B'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Tpp+Binding+Site+For+Chain+B'>AC1</scene> | ||
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OS:OSMIUM+ION'>OS</scene> | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OS:OSMIUM+ION'>OS</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cky OCA], [http://www.ebi.ac.uk/pdbsum/2cky PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cky RCSB]</span> | |||
}} | }} | ||
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[[Category: Leibundgut, M.]] | [[Category: Leibundgut, M.]] | ||
[[Category: Thore, S.]] | [[Category: Thore, S.]] | ||
[[Category: nucleic acid]] | [[Category: nucleic acid]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:22:56 2008'' | ||
Revision as of 23:22, 30 March 2008
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| 2cky, resolution 2.90Å | |||||||||||||
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| Sites: | AC1 | ||||||||||||
| Ligands: | A, C, G, MG, OS, TPP, U | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand
Overview
Riboswitches are untranslated regions of messenger RNA, which adopt alternate structures depending on the binding of specific metabolites. Such conformational switching regulates the expression of proteins involved in the biosynthesis of riboswitch substrates. Here, we present the 2.9 angstrom-resolution crystal structure of the eukaryotic Arabidopsis thaliana thiamine pyrophosphate (TPP)-specific riboswitch in complex with its natural ligand. The riboswitch specifically recognizes the TPP via conserved residues located within two highly distorted parallel "sensor" helices. The structure provides the basis for understanding the reorganization of the riboswitch fold upon TPP binding and explains the mechanism of resistance to the antibiotic pyrithiamine.
About this Structure
2CKY is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand., Thore S, Leibundgut M, Ban N, Science. 2006 May 26;312(5777):1208-11. Epub 2006 May 4. PMID:16675665
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