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==Crystal structure of hcv ns5b polymerase with a novel benzisothiazole inhibitor==
==Crystal structure of hcv ns5b polymerase with a novel benzisothiazole inhibitor==
<StructureSection load='3d28' size='340' side='right' caption='[[3d28]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3d28' size='340' side='right' caption='[[3d28]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3d28]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D28 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3d28]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hcv Hcv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D28 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B34:(5S)-1-BENZYL-3-(1,1-DIOXIDO-1,2-BENZISOTHIAZOL-3-YL)-4-HYDROXY-5-(1-METHYLETHYL)-1,5-DIHYDRO-2H-PYRROL-2-ONE'>B34</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B34:(5S)-1-BENZYL-3-(1,1-DIOXIDO-1,2-BENZISOTHIAZOL-3-YL)-4-HYDROXY-5-(1-METHYLETHYL)-1,5-DIHYDRO-2H-PYRROL-2-ONE'>B34</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bsc|3bsc]], [[3br9|3br9]], [[3bsa|3bsa]], [[3cde|3cde]], [[3cwj|3cwj]], [[3co9|3co9]], [[3cvk|3cvk]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bsc|3bsc]], [[3br9|3br9]], [[3bsa|3bsa]], [[3cde|3cde]], [[3cwj|3cwj]], [[3co9|3co9]], [[3cvk|3cvk]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d28 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d28 RCSB], [http://www.ebi.ac.uk/pdbsum/3d28 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d28 OCA], [http://pdbe.org/3d28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d28 RCSB], [http://www.ebi.ac.uk/pdbsum/3d28 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3d28 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3d28" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hcv]]
[[Category: RNA-directed RNA polymerase]]
[[Category: RNA-directed RNA polymerase]]
[[Category: Viruses]]
[[Category: Han, Q]]
[[Category: Han, Q]]
[[Category: Kissinger, C R]]
[[Category: Kissinger, C R]]
Retrieved from "https://proteopedia.org/3d28"