2d47: Difference between revisions
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|PDB= 2d47 |SIZE=350|CAPTION= <scene name='initialview01'>2d47</scene>, resolution 2.000Å | |PDB= 2d47 |SIZE=350|CAPTION= <scene name='initialview01'>2d47</scene>, resolution 2.000Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=SPM:SPERMINE'>SPM</scene> | |LIGAND= <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d47 OCA], [http://www.ebi.ac.uk/pdbsum/2d47 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2d47 RCSB]</span> | |||
}} | }} | ||
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[[Category: Subirana, J A.]] | [[Category: Subirana, J A.]] | ||
[[Category: Verdaguer, N.]] | [[Category: Verdaguer, N.]] | ||
[[Category: a-dna]] | [[Category: a-dna]] | ||
[[Category: double helix]] | [[Category: double helix]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:30:05 2008'' | ||
Revision as of 23:30, 30 March 2008
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| 2d47, resolution 2.000Å | |||||||||||||
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| Ligands: | DC, DG, SPM | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA
Overview
We have determined the crystal structure of the dodecamer d(CCCCCGCGGGGG), showing for the first time a complete turn of A-DNA. It has average structural parameters similar to those determined in fibres. Nevertheless it shows a considerable local variation in structure which is in part associated with the presence of a bound spermine molecule. We conclude that the local DNA conformation does not only depend on the base sequence, but may be strongly modified upon interaction with other molecules. In particular, the CpG sequence, which is found in hypersensitive regions of the genome, appears to be able to easily change its conformation under external influences.
About this Structure
2D47 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Molecular structure of a complete turn of A-DNA., Verdaguer N, Aymami J, Fernandez-Forner D, Fita I, Coll M, Huynh-Dinh T, Igolen J, Subirana JA, J Mol Biol. 1991 Sep 20;221(2):623-35. PMID:1920437
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