2dw0: Difference between revisions
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|PDB= 2dw0 |SIZE=350|CAPTION= <scene name='initialview01'>2dw0</scene>, resolution 2.15Å | |PDB= 2dw0 |SIZE=350|CAPTION= <scene name='initialview01'>2dw0</scene>, resolution 2.15Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GM6:3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE'>GM6</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[2dw1|2DW1]], [[2dw2|2DW2]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dw0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dw0 OCA], [http://www.ebi.ac.uk/pdbsum/2dw0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dw0 RCSB]</span> | |||
}} | }} | ||
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[[Category: Igarashi, T.]] | [[Category: Igarashi, T.]] | ||
[[Category: Takeda, S.]] | [[Category: Takeda, S.]] | ||
[[Category: apoptotic toxin]] | [[Category: apoptotic toxin]] | ||
[[Category: metalloproteinase]] | [[Category: metalloproteinase]] | ||
[[Category: svmp]] | [[Category: svmp]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:40:20 2008'' | ||
Revision as of 23:40, 30 March 2008
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| 2dw0, resolution 2.15Å | |||||||||||||
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| Ligands: | BMA, CA, GM6, MAN, NAG, ZN | ||||||||||||
| Related: | 2DW1, 2DW2
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of VAP2 from Crotalus atrox venom (Form 2-1 crystal)
Overview
Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. The overall structures show good agreement with both monomers of atypical homodimeric VAP1. Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins.
About this Structure
2DW0 is a Single protein structure of sequence from Crotalus atrox. Full crystallographic information is available from OCA.
Reference
Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins., Igarashi T, Araki S, Mori H, Takeda S, FEBS Lett. 2007 May 29;581(13):2416-22. Epub 2007 Apr 30. PMID:17485084
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