3shw: Difference between revisions
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==Crystal structure of ZO-1 PDZ3-SH3-Guk supramodule complex with Connexin-45 peptide== | ==Crystal structure of ZO-1 PDZ3-SH3-Guk supramodule complex with Connexin-45 peptide== | ||
<StructureSection load='3shw' size='340' side='right' caption='[[3shw]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='3shw' size='340' side='right' caption='[[3shw]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3shw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3shw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SHW FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3shu|3shu]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3shu|3shu]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3shw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3shw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3shw RCSB], [http://www.ebi.ac.uk/pdbsum/3shw PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3shw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3shw OCA], [http://pdbe.org/3shw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3shw RCSB], [http://www.ebi.ac.uk/pdbsum/3shw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3shw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> | [[http://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> [[http://www.uniprot.org/uniprot/CXG1_HUMAN CXG1_HUMAN]] One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Chen, J]] | [[Category: Chen, J]] | ||
[[Category: Pan, L]] | [[Category: Pan, L]] | ||
