2eb3: Difference between revisions
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|PDB= 2eb3 |SIZE=350|CAPTION= <scene name='initialview01'>2eb3</scene>, resolution 2.84Å | |PDB= 2eb3 |SIZE=350|CAPTION= <scene name='initialview01'>2eb3</scene>, resolution 2.84Å | ||
|SITE= <scene name='pdbsite=AC1:Anp+Binding+Site+For+Residue+A+2001'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Anp+Binding+Site+For+Residue+A+2001'>AC1</scene> | ||
|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER'>ANP</scene> | |LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span> | ||
|GENE= EGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= EGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[2eb2|2EB2]], [[2zge|2ZGE]], [[2zgf|2ZGF]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb3 OCA], [http://www.ebi.ac.uk/pdbsum/2eb3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2eb3 RCSB]</span> | |||
}} | }} | ||
'''Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP''' | '''Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP''' | ||
==Disease== | |||
Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]] | |||
==About this Structure== | ==About this Structure== | ||
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[[Category: Yokoyama, S.]] | [[Category: Yokoyama, S.]] | ||
[[Category: Yoshikawa, S.]] | [[Category: Yoshikawa, S.]] | ||
[[Category: atp-binding]] | [[Category: atp-binding]] | ||
[[Category: cell cycle]] | [[Category: cell cycle]] | ||
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[[Category: tyrosine-protein kinase]] | [[Category: tyrosine-protein kinase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:46:23 2008'' | ||
