4au8: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
==Crystal structure of compound 4a in complex with cdk5, showing an unusual binding mode to the hinge region via a water molecule==
==Crystal structure of compound 4a in complex with cdk5, showing an unusual binding mode to the hinge region via a water molecule==
<StructureSection load='4au8' size='340' side='right' caption='[[4au8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4au8' size='340' side='right' caption='[[4au8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4au8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AU8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4au8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AU8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z3R:4-(1,3-BENZOTHIAZOL-2-YL)THIOPHENE-2-SULFONAMIDE'>Z3R</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z3R:4-(1,3-BENZOTHIAZOL-2-YL)THIOPHENE-2-SULFONAMIDE'>Z3R</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h4l|1h4l]], [[1lfr|1lfr]], [[1ung|1ung]], [[1unh|1unh]], [[1unl|1unl]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h4l|1h4l]], [[1lfr|1lfr]], [[1ung|1ung]], [[1unh|1unh]], [[1unl|1unl]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4au8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4au8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4au8 RCSB], [http://www.ebi.ac.uk/pdbsum/4au8 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4au8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4au8 OCA], [http://pdbe.org/4au8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4au8 RCSB], [http://www.ebi.ac.uk/pdbsum/4au8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4au8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
Line 18: Line 19:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4au8" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cyclin-dependent kinase|Cyclin-dependent kinase]]
== References ==
== References ==
<references/>
<references/>
Line 23: Line 28:
</StructureSection>
</StructureSection>
[[Category: Cyclin-dependent kinase]]
[[Category: Cyclin-dependent kinase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Aagaard, A]]
[[Category: Aagaard, A]]
[[Category: Costa, A]]
[[Category: Costa, A]]
Retrieved from "https://proteopedia.org/4au8"