2f71: Difference between revisions

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|PDB= 2f71 |SIZE=350|CAPTION= <scene name='initialview01'>2f71</scene>, resolution 1.550&Aring;
|PDB= 2f71 |SIZE=350|CAPTION= <scene name='initialview01'>2f71</scene>, resolution 1.550&Aring;
|SITE=  
|SITE=  
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=UN7:3-[3-(3(S)-METHYLCARBAMOYL-7-SULFOAMINO-3,4,-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3-OXO-PROPYL]-BENZOIC ACID'>UN7</scene>
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UN7:3-[3-(3(S)-METHYLCARBAMOYL-7-SULFOAMINO-3,4,-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3-OXO-PROPYL]-BENZOIC+ACID'>UN7</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]  
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
|GENE= PTPN1, PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= PTPN1, PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|DOMAIN=
|RELATEDENTRY=[[2f6t|2F6T]], [[2f6v|2F6V]], [[2f6w|2F6W]], [[2f6y|2F6Y]], [[2f7z|2F7Z]], [[2f70|2F70]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f71 OCA], [http://www.ebi.ac.uk/pdbsum/2f71 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f71 RCSB]</span>
}}
}}


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==Overview==
==Overview==
High-throughput screening of the P&amp;GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.
High-throughput screening of the P&amp;GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.
==Disease==
Known diseases associated with this structure: Abdominal body fat distribution, modifier of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176885 176885]], Insulin resistance, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176885 176885]]


==About this Structure==
==About this Structure==
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[[Category: Klopfenstein, S R.]]
[[Category: Klopfenstein, S R.]]
[[Category: Pokross, M E.]]
[[Category: Pokross, M E.]]
[[Category: CL]]
[[Category: MG]]
[[Category: UN7]]
[[Category: phosphatase]]
[[Category: phosphatase]]
[[Category: ptp1b]]
[[Category: ptp1b]]
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[[Category: tyrosine]]
[[Category: tyrosine]]


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