3i6o: Difference between revisions

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==Crystal structure of wild type HIV-1 protease with macrocyclic inhibitor GRL-0216A==
==Crystal structure of wild type HIV-1 protease with macrocyclic inhibitor GRL-0216A==
<StructureSection load='3i6o' size='340' side='right' caption='[[3i6o]], [[Resolution|resolution]] 1.17&Aring;' scene=''>
<StructureSection load='3i6o' size='340' side='right' caption='[[3i6o]], [[Resolution|resolution]] 1.17&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3i6o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I6O FirstGlance]. <br>
<table><tr><td colspan='2'>[[3i6o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-1 Hiv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I6O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GR6:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL+{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(7E)-13-METHOXY-1,1-DIOXIDO-3,4,5,6,9,10-HEXAHYDRO-2H-11,1,2-BENZOXATHIAZACYCLOTRIDECIN-2-YL]PROPYL}CARBAMATE'>GR6</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GR6:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL+{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(7E)-13-METHOXY-1,1-DIOXIDO-3,4,5,6,9,10-HEXAHYDRO-2H-11,1,2-BENZOXATHIAZACYCLOTRIDECIN-2-YL]PROPYL}CARBAMATE'>GR6</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ien|2ien]], [[2z4o|2z4o]], [[3djk|3djk]], [[3dk1|3dk1]], [[3h5b|3h5b]], [[2hb3|2hb3]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ien|2ien]], [[2z4o|2z4o]], [[3djk|3djk]], [[3dk1|3dk1]], [[3h5b|3h5b]], [[2hb3|2hb3]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11686 HIV-1])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i6o RCSB], [http://www.ebi.ac.uk/pdbsum/3i6o PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i6o OCA], [http://pdbe.org/3i6o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i6o RCSB], [http://www.ebi.ac.uk/pdbsum/3i6o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i6o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i6o ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3i6o" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Viruses]]
[[Category: Hiv-1]]
[[Category: Chumanevich, A A]]
[[Category: Chumanevich, A A]]
[[Category: Kovalevsky, A Y]]
[[Category: Kovalevsky, A Y]]
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[[Category: Aid]]
[[Category: Aid]]
[[Category: Aspartyl protease]]
[[Category: Aspartyl protease]]
[[Category: Hiv-1]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Macrocyclic ligand]]
[[Category: Macrocyclic ligand]]
[[Category: Protease inhibitor]]
[[Category: Protease inhibitor]]
[[Category: Wild type protease]]
[[Category: Wild type protease]]
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