2fjn: Difference between revisions

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|PDB= 2fjn |SIZE=350|CAPTION= <scene name='initialview01'>2fjn</scene>, resolution 2.20&Aring;
|PDB= 2fjn |SIZE=350|CAPTION= <scene name='initialview01'>2fjn</scene>, resolution 2.20&Aring;
|SITE=  
|SITE=  
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=073:(4-{(2S,4E)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-2-[4-(METHOXYCARBONYL)PHENYL]-5-PHENYLPENT-4-ENYL}PHENYL)(DIFLUORO)METHYLPHOSPHONIC ACID'>073</scene>
|LIGAND= <scene name='pdbligand=073:(4-{(2S,4E)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-2-[4-(METHOXYCARBONYL)PHENYL]-5-PHENYLPENT-4-ENYL}PHENYL)(DIFLUORO)METHYLPHOSPHONIC+ACID'>073</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]  
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
|GENE= PTPN1, PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= PTPN1, PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|DOMAIN=
|RELATEDENTRY=[[2fjm|2FJM]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fjn OCA], [http://www.ebi.ac.uk/pdbsum/2fjn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fjn RCSB]</span>
}}
}}


'''The structure of phosphotyrosine phosphatase 1B in complex with compound 2'''
'''The structure of phosphotyrosine phosphatase 1B in complex with compound 2'''


==Disease==
Known diseases associated with this structure: Abdominal body fat distribution, modifier of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176885 176885]], Insulin resistance, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176885 176885]]


==About this Structure==
==About this Structure==
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[[Category: Taylor, J.]]
[[Category: Taylor, J.]]
[[Category: Therien, M.]]
[[Category: Therien, M.]]
[[Category: 073]]
[[Category: CL]]
[[Category: phosphatase]]
[[Category: phosphatase]]
[[Category: secondary binding site]]
[[Category: secondary binding site]]
[[Category: selectivity]]
[[Category: selectivity]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:53:10 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:03:45 2008''
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