Practical Guide to Homology Modeling: Difference between revisions
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Examples: | Examples: | ||
*Folded: Pyruvate kinase (length 531; e.g. [http://mobidb.bio.unipd.it/entries/P11979 P11979, KPYM_FELCA]) has no disordered regions. The crystal structure (1pkm) lacks only 11 residues at the C terminus. | *Folded: Pyruvate kinase (length 531; e.g. [http://mobidb.bio.unipd.it/entries/P11979 P11979, KPYM_FELCA]) has no disordered regions. The crystal structure (1pkm) lacks only 11 residues at the C terminus. | ||
*Partially folded: The tumor suppressor protein p53 (length 393; e.g. http://mobidb.bio.unipd.it/entries/P04637 P04637, P53_HUMAN]) is intrinsically disordered at both the N and C termini. There are many crystallographic structures for the folded mid-region (~200 residues), which lack coordinates for 90-some residues at the N terminus, and 90-some at the C terminus. Some solution NMR structures of the N terminus illustrate the disorder (e.g. 2ly4). | *Partially folded: The tumor suppressor protein p53 (length 393; e.g. [http://mobidb.bio.unipd.it/entries/P04637 P04637, P53_HUMAN]) is intrinsically disordered at both the N and C termini. There are many crystallographic structures for the folded mid-region (~200 residues), which lack coordinates for 90-some residues at the N terminus, and 90-some at the C terminus. Some solution NMR structures of the N terminus illustrate the disorder (e.g. 2ly4). | ||
*Unfolded: Caldesmon from chicken gizzard (length 771; [http://mobidb.bio.unipd.it/entries/P12957 P12957, CALD1_CHICK]) has no crystal structures, and is predicted to be disordered for essentially its full length. | *Unfolded: Caldesmon from chicken gizzard (length 771; [http://mobidb.bio.unipd.it/entries/P12957 P12957, CALD1_CHICK]) has no crystal structures, and is predicted to be disordered for essentially its full length. | ||
