Tachyplesin: Difference between revisions

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Tachyplesin I (TPI) is an [http://en.wikipedia.org/wiki/Antimicrobial_peptides antimicrobial polypeptide] originally detected in Japanese [http://en.wikipedia.org/wiki/Horseshoe_crab Horse Shoe Crab].

The antimicrobial activity of peptides is closely related to the composition of the pathogen membrane. Bacteria and fungi have negatively charged membranes, and the interaction of <scene name='67/671725/Cationic_peptide_tpi/1'>cationic peptides such as tachyplesin I </scene>~~{{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}~~} is mediated in large part by electrostatic interactions.<ref name=Laederach>PMID:12369825</ref>

The antimicrobial activity of peptides is closely related to the composition of the pathogen membrane. Bacteria and fungi have negatively charged membranes, and the interaction of <scene name='67/671725/Cationic_peptide_tpi/1'>cationic peptides such as tachyplesin I </scene>} is mediated in large part by electrostatic interactions<ref name=Laederach>PMID:12369825</ref> (yoa can see the {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar} amino acids).

It shows high affinity for [http://en.wikipedia.org/wiki/Lipopolysaccharide lipopolysaccharides (LPS)] of [http://en.wikipedia.org/wiki/Gram-negative_bacteria gram-negative bacteria], thus neutralizing its effects. It has also been reported to inhibit the growth of gram positive bacteria, fungui and viruses.

Tachyplesin: Difference between revisions

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 <StructureSection load='1MA2' size='340' side='right' caption='1MA2' scene=''>
 Tachyplesin I (TPI) is an [http://en.wikipedia.org/wiki/Antimicrobial_peptides antimicrobial polypeptide] originally detected in Japanese [http://en.wikipedia.org/wiki/Horseshoe_crab Horse Shoe Crab].
-The antimicrobial activity of peptides is closely related to the composition of the pathogen membrane. Bacteria and fungi have negatively charged membranes, and the interaction of <scene name='67/671725/Cationic_peptide_tpi/1'>cationic peptides such as tachyplesin I </scene>{{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}} is mediated in large part by electrostatic interactions.<ref name=Laederach>PMID:12369825</ref>
+The antimicrobial activity of peptides is closely related to the composition of the pathogen membrane. Bacteria and fungi have negatively charged membranes, and the interaction of <scene name='67/671725/Cationic_peptide_tpi/1'>cationic peptides such as tachyplesin I </scene>} is mediated in large part by electrostatic interactions<ref name=Laederach>PMID:12369825</ref> (yoa can see the {{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar} amino acids).
 It shows high affinity for [http://en.wikipedia.org/wiki/Lipopolysaccharide lipopolysaccharides (LPS)] of [http://en.wikipedia.org/wiki/Gram-negative_bacteria gram-negative bacteria], thus neutralizing its effects. It has also been reported to inhibit the growth  of gram positive bacteria, fungui and viruses.