Tachyplesin: Difference between revisions
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Tachyplesin I (TPI) is an [http://en.wikipedia.org/wiki/Antimicrobial_peptides antimicrobial polypeptide] originally detected in Japanese [http://en.wikipedia.org/wiki/Horseshoe_crab Horse Shoe Crab]. | Tachyplesin I (TPI) is an [http://en.wikipedia.org/wiki/Antimicrobial_peptides antimicrobial polypeptide] originally detected in Japanese [http://en.wikipedia.org/wiki/Horseshoe_crab Horse Shoe Crab]. | ||
The antimicrobial activity of peptides is closely related to the composition of the pathogen membrane. Bacteria and fungi have negatively charged membranes, and the interaction of <scene name='67/671725/Cationic_peptide_tpi/1'>cationic peptides such as tachyplesin I </scene> is mediated in large part by electrostatic interactions<ref name=Laederach>PMID:12369825</ref> (you can see the {{Template:ColorKey_Hydrophobic}} and {{Template:ColorKey_Polar}} amino acids). | The antimicrobial activity of peptides is closely related to the composition of the pathogen membrane. Bacteria and fungi have negatively charged membranes, and the interaction of <scene name='67/671725/Cationic_peptide_tpi/1'>cationic peptides such as tachyplesin I </scene> is mediated in large part by electrostatic interactions<ref name=Laederach>PMID:12369825</ref> (you can see the {{Template:ColorKey_Hydrophobic}} and {{Template:ColorKey_Polar}} amino acids). | ||
It shows high affinity for [http://en.wikipedia.org/wiki/Lipopolysaccharide lipopolysaccharides (LPS)] of [http://en.wikipedia.org/wiki/Gram-negative_bacteria gram-negative bacteria], thus neutralizing its effects. It has also been reported to inhibit the growth of gram positive bacteria, fungui and viruses. | It shows high affinity for [http://en.wikipedia.org/wiki/Lipopolysaccharide lipopolysaccharides (LPS)] of [http://en.wikipedia.org/wiki/Gram-negative_bacteria gram-negative bacteria], thus neutralizing its effects. It has also been reported to inhibit the growth of gram positive bacteria, fungui and viruses. | ||
