Sandbox Reserved 962: Difference between revisions
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== Interaction == | == Interaction == | ||
=== Interaction with a Cap | === Interaction with a Cap Analog (7-methylguanosine-5-triphosphate-5-Guanosine)=== | ||
<scene name='60/604481/Gtg/2'>Cap | <scene name='60/604481/Gtg/2'>Cap analog</scene> | ||
===Interaction with AdoHcy (S-adenosyl-L-homocysteine)=== | ===Interaction with AdoHcy (S-adenosyl-L-homocysteine)=== | ||
The mRNA Cap Methyltransferase bind to <scene name='60/604481/Sah/1'>AdoHcy</scene> which is the product of the methyl donor AdoMet after the methylation. | The mRNA Cap Methyltransferase bind to <scene name='60/604481/Sah/1'>AdoHcy</scene> which is the product of the methyl donor AdoMet after the methylation. | ||
AdoHcys is in a pocket formed by amino acids of segment 2. | |||
<scene name='60/604481/Interaction_sah/1'>10 amino acids</scene> (Lys54, Gly72, Asp78, Asp94, Ile95, Asp122, Ser124, Gln140, Phe141, Ser142) are involved in the stabilisation of AdoHcys. | <scene name='60/604481/Interaction_sah/1'>10 amino acids</scene> (Lys54, Gly72, Asp78, Asp94, Ile95, Asp122, Ser124, Gln140, Phe141, Ser142) are involved in the stabilisation of AdoHcys. | ||
The interactions between AdoHcys and the enzyme are made of : hydrogen bonds, Van der Walls interactions,electrostatic interaction and water mediated contact. | The interactions between AdoHcys and the enzyme are made of : hydrogen bonds, Van der Walls interactions,electrostatic interaction and water mediated contact. | ||
