Tachyplesin: Difference between revisions
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It adopts antiparallel β-sheet (hairpin) conformation in solution stabilized by two cross-strand <scene name='67/671725/Disulfide_bonds/1'> disulfide bonds </scene> between Cys³-Cys¹⁶ and Cys⁷-Cys¹², and its [http://en.wikipedia.org/wiki/Protein_primary_structure C-terminus is amidated].<ref name=Laederach>PMID:12369825</ref><ref name=Kushibiki>PMID:24389234</ref> | It adopts antiparallel β-sheet (hairpin) conformation in solution stabilized by two cross-strand <scene name='67/671725/Disulfide_bonds/1'> disulfide bonds </scene> between Cys³-Cys¹⁶ and Cys⁷-Cys¹², and its [http://en.wikipedia.org/wiki/Protein_primary_structure C-terminus is amidated].<ref name=Laederach>PMID:12369825</ref><ref name=Kushibiki>PMID:24389234</ref> | ||
[[Image:scheme.jpg]] | [[Image:scheme.jpg|150px|left|thumb|<b>Figure 1: Drown simplefied tachyplesin I.</b>]] | ||
Tachyplesin is highly stable at low pH and high temperature. This stability seems to be due to the rigid structure imposed by the two disulfid linkage.<ref name=Nakamura>Nakamura, Takanori, et al. "Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (Tachypleus tridentatus). Isolation and chemical structure." Journal of Biological Chemistry 263.32 (1988): 16709-16713</ref> | Tachyplesin is highly stable at low pH and high temperature. This stability seems to be due to the rigid structure imposed by the two disulfid linkage.<ref name=Nakamura>Nakamura, Takanori, et al. "Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (Tachypleus tridentatus). Isolation and chemical structure." Journal of Biological Chemistry 263.32 (1988): 16709-16713</ref> | ||
Besides, there exists H-bond and aromatic ring stacking interactions which helps stabilizing the hairpin loop structure of the peptide. | Besides, there exists H-bond and aromatic ring stacking interactions which helps stabilizing the hairpin loop structure of the peptide. | ||
Along with TPI, there exists three linear derivatives: <scene name='67/671725/1ma4/3'>TPY4</scene>, TPF4 and TPA4 as shown below. | Along with TPI, there exists three linear derivatives: <scene name='67/671725/1ma4/3'>TPY4</scene>, TPF4 and TPA4 as shown below. | ||
[[Image:derivatives.jpg]] | [[Image:derivatives.jpg]] | ||
