Sandbox Reserved 962: Difference between revisions
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== Mechanism== | == Mechanism== | ||
This enzyme catalyse N-methyl transfer from AdoMet (S-adenosylmethionine) to GpppRNA, this reaction produce 7-methyl-GpppRNA and AdoHcy. | This enzyme catalyse N-methyl transfer from AdoMet (S-adenosylmethionine) to GpppRNA, this reaction produce 7-methyl-GpppRNA and AdoHcy. This reaction is made trough a SN2 mechanism. | ||
We remark that the enzyme do not stabilize the transition state of the chemical reaction, do not promote the activation of the nucleophile or the explusion of the leaving group. mRNA Cap Methyltransferase orientates the substrates to facilitate the methyl transfer. | We remark that the enzyme do not stabilize the transition state of the chemical reaction, do not promote the activation of the nucleophile or the explusion of the leaving group. mRNA Cap Methyltransferase brings the two substrates closer and orientates the substrates to facilitate the methyl transfer. | ||
== References == | == References == | ||
<references/> | <references/> | ||
