Sandbox Reserved 962: Difference between revisions
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=== Cap Analog Binding (7-methylguanosine-5-triphosphate-5-Guanosine)=== | === Cap Analog Binding (7-methylguanosine-5-triphosphate-5-Guanosine)=== | ||
<scene name='60/604481/Gtg/ | <scene name='60/604481/Gtg/3'>A cap analog</scene> binds to the enzyme in a pocket near the AdoHcy. | ||
<scene name='60/604481/Interaction_gtg/1'>6 amino acids</scene> (Tyr 145, Leu216, Leu217, Asp218, Ser219, Tyr284) are involded in the binding of the cap analog. | <scene name='60/604481/Interaction_gtg/1'>6 amino acids</scene> (Tyr 145, Leu216, Leu217, Asp218, Ser219, Tyr284) are involded in the binding of the cap analog. | ||
The cap makes Van der Walls contacts, hydrogen bond and water mediated bond. | The cap makes Van der Walls contacts, hydrogen bond and water mediated bond. | ||
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=== AdoHcy Binding (S-adenosyl-L-homocysteine)=== | === AdoHcy Binding (S-adenosyl-L-homocysteine)=== | ||
The mRNA Cap Methyltransferase bind to <scene name='60/604481/Sah/ | The mRNA Cap Methyltransferase bind to <scene name='60/604481/Sah/2'>AdoHcy</scene> which is the product of the methyl donor AdoMet after the methylation. | ||
AdoHcys is in a pocket formed by amino acids of segment 2. | AdoHcys is in a pocket formed by amino acids of segment 2. | ||
<scene name='60/604481/Interaction_sah/1'>10 amino acids</scene> (Lys54, Gly72, Asp78, Asp94, Ile95, Asp122, Ser124, Gln140, Phe141, Ser142) are involved in the stabilisation of AdoHcys. | <scene name='60/604481/Interaction_sah/1'>10 amino acids</scene> (Lys54, Gly72, Asp78, Asp94, Ile95, Asp122, Ser124, Gln140, Phe141, Ser142) are involved in the stabilisation of AdoHcys. | ||
