Tachyplesin: Difference between revisions
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The structural nature of tachyplesin suggested that it might also posses antitumor properties. Since it can interact with the membrance of prokaryotic cell, it is likely that TP I can also interact with the mitochondrial membrane of eukaryotic cells due to the structure similarity of these membranes because mitochondria are widely belived to have evolved from prokaryotic cells that have established a symbiotic relationship with the promitive eukaryotic cell. | The structural nature of tachyplesin suggested that it might also posses antitumor properties. Since it can interact with the membrance of prokaryotic cell, it is likely that TP I can also interact with the mitochondrial membrane of eukaryotic cells due to the structure similarity of these membranes because mitochondria are widely belived to have evolved from prokaryotic cells that have established a symbiotic relationship with the promitive eukaryotic cell. | ||
It was found that the synthetic RGD-tachyplesin | It was found that the synthetic RGD-tachyplesin can inhibit the [http://en.wikipedia.org/wiki/Cell_growth proliferation] of TSU [http://en.wikipedia.org/wiki/Prostate_cancer prostate cancer] cells and B16 [http://en.wikipedia.org/wiki/Melanoma melanoma] cells as well as [http://en.wikipedia.org/wiki/Endothelium endothelial cells] in a dose-dependent mannar <i>in vitro</i> and reduce tumor growth <i>in vivo</i> by inducing [http://en.wikipedia.org/wiki/Apoptosis apoptosis].<ref name=Chen>Chen, Yixin, et al. "RGD-Tachyplesin inhibits tumor growth." Cancer research 61.6 (2001): 2434-2438.</ref> | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
