Sandbox Reserved 970: Difference between revisions
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The protein is very rich in <scene name='60/604489/Alpha_regions/1'>alpha helices regions</scene>. It contains 10 transmembrane alpha helices, and three of them line a channel that spans the lipid bilayer and that allows calcium to pass through membranes. When the protein isn’t phosphorylated, two of the transmembrane helices are disrupted and form a cavity that can bind two molecules of calcium. | The protein is very rich in <scene name='60/604489/Alpha_regions/1'>alpha helices regions</scene>. It contains 10 transmembrane alpha helices, and three of them line a channel that spans the lipid bilayer and that allows calcium to pass through membranes. When the protein isn’t phosphorylated, two of the transmembrane helices are disrupted and form a cavity that can bind two molecules of calcium. | ||
The calcium pump is organized in four major domains: | The calcium pump is organized in four major domains: The transmembrane portion of the protein contains the channel that span the lipid bilayer, and the calcium binding cavity; The nucleotide binding domain, where ATP binds to the protein; The phosphorylation domain contains an Aspartate residue (Asp 351) that can be phosphorylated and the activator domain. | ||
The transmembrane portion of the protein contains the channel that span the lipid bilayer, and the calcium binding cavity | |||
The nucleotide binding domain, where ATP binds to the protein | |||
The phosphorylation domain contains an Aspartate residue (Asp 351) that can be phosphorylated | |||
