Sandbox Reserved 970: Difference between revisions

Line 9:

The calcium ATPase is a protein composed of 1001 aminoacids.

The protein is very rich in <scene name='60/604489/Alpha_regions/1'>alpha helices regions</scene>. It contains 10 transmembrane alpha helices, and three of them line a channel that spans the lipid bilayer and that allows calcium to pass through membranes. It also contains too cytoplasmic loops between the thransmembrane helices. When the protein isn’t phosphorylated, two of the transmembrane helices are disrupted and form a cavity that can bind two molecules of calcium.

The protein is very rich in <scene name='60/604489/Alpha_regions/1'>alpha helices regions</scene>. It contains <scene name='60/604489/Transmembrane_domain/1'>10 transmembrane alpha helices</scene>, and three of them line a channel that spans the lipid bilayer and that allows calcium to pass through membranes. It also contains too cytoplasmic loops between the thransmembrane helices. When the protein isn’t phosphorylated, two of the transmembrane helices are disrupted and form a cavity that can bind two molecules of calcium.

~~The '''transmembrane portion'~~'' of the protein contains the channel that span the lipid bilayer, and the calcium binding cavity.

<scene name='60/604489/The_4_domains_of_the_pump/1'>4 regions</scene>. The of the protein contains the channel that span the lipid bilayer, and the calcium binding cavity.

The two cytoplasmic loops form three separate domains. The '''nucleotide binding domain~~'''~~ (N) contains the site where ATP binds to the protein. The '''phosphorylation domain~~'''~~ (P) contains an Aspartate residue (Asp 351) that can be phosphorylated. Finally, the '''actuator domain~~'''~~ (A) is involved in the transmission of major conformational changes. The phosphorylation and the nucleotide binding domains form the '''catalytic site''' of the protein.

The two cytoplasmic loops form three separate domains. The <scene name='60/604489/Nucleotide_binding_domain/1'>nucleotide binding domain (N)</scene> contains the site where ATP binds to the protein. The <scene name='60/604489/P_domain/1'>phosphorylation domain (P)</scene> contains an Aspartate residue (Asp 351) that can be phosphorylated. Finally, the <scene name='60/604489/Actuator_domain/1'>actuator domain (A)</scene> is involved in the transmission of major conformational changes. The phosphorylation and the nucleotide binding domains form the '''catalytic site''' of the protein.

Sandbox Reserved 970: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 9: / Line 9: @@
 The calcium ATPase is a protein composed of 1001 aminoacids.
-The protein is very rich in <scene name='60/604489/Alpha_regions/1'>alpha helices regions</scene>. It contains 10 transmembrane alpha helices, and three of them line a channel that spans the lipid bilayer and that allows calcium to pass through membranes. It also contains too cytoplasmic loops between the thransmembrane helices. When the protein isn’t phosphorylated, two of the transmembrane helices are disrupted and form a cavity that can bind two molecules of calcium.
+The protein is very rich in <scene name='60/604489/Alpha_regions/1'>alpha helices regions</scene>. It contains <scene name='60/604489/Transmembrane_domain/1'>10 transmembrane alpha helices</scene>, and three of them line a channel that spans the lipid bilayer and that allows calcium to pass through membranes. It also contains too cytoplasmic loops between the thransmembrane helices. When the protein isn’t phosphorylated, two of the transmembrane helices are disrupted and form a cavity that can bind two molecules of calcium.
-The '''transmembrane portion''' of the protein contains the channel that span the lipid bilayer, and the calcium binding cavity.
+<scene name='60/604489/The_4_domains_of_the_pump/1'>4 regions</scene>. The  of the protein contains the channel that span the lipid bilayer, and the calcium binding cavity.
-The two cytoplasmic loops form three separate domains. The '''nucleotide binding domain''' (N) contains the site where ATP binds to the protein. The '''phosphorylation domain''' (P) contains an Aspartate residue (Asp 351) that can be phosphorylated. Finally, the '''actuator domain''' (A) is involved in the transmission of major conformational changes. The phosphorylation and the nucleotide binding domains form the '''catalytic site''' of the protein.
+The two cytoplasmic loops form three separate domains. The <scene name='60/604489/Nucleotide_binding_domain/1'>nucleotide binding domain (N)</scene> contains the site where ATP binds to the protein. The <scene name='60/604489/P_domain/1'>phosphorylation domain (P)</scene> contains an Aspartate residue (Asp 351) that can be phosphorylated. Finally, the <scene name='60/604489/Actuator_domain/1'>actuator domain (A)</scene> is involved in the transmission of major conformational changes. The phosphorylation and the nucleotide binding domains form the '''catalytic site''' of the protein.