Sandbox Reserved 963: Difference between revisions
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Moreover, thanks to temperature-factors analysis, it appears that CDR H1 is much less flexible in the liganted structure.<ref>Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope.,Miles LA, Wun KS, Crespi GA, Fodero-Tavoletti MT, Galatis D, Bagley CJ, Beyreuther K, Masters CL, Cappai R, McKinstry WJ, Barnham KJ, Parker MW J Mol Biol. 2008 Mar 14;377(1):181-92. Epub 2008 Jan 30. PMID:18237744</ref> | Moreover, thanks to temperature-factors analysis, it appears that CDR H1 is much less flexible in the liganted structure.<ref>Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope.,Miles LA, Wun KS, Crespi GA, Fodero-Tavoletti MT, Galatis D, Bagley CJ, Beyreuther K, Masters CL, Cappai R, McKinstry WJ, Barnham KJ, Parker MW J Mol Biol. 2008 Mar 14;377(1):181-92. Epub 2008 Jan 30. PMID:18237744</ref> | ||
== | == Biological Relevance == | ||
One of the most common isoforms of Aβ is the 42-mer Aβ (its sequence is 1-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-42), which is the most fibrillogenic isoforms and is therefore linked to disease states. | One of the most common isoforms of Aβ is the 42-mer Aβ (its sequence is 1-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-42), which is the most fibrillogenic isoforms and is therefore linked to disease states. | ||
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*PFA1, PFA2 | *PFA1, PFA2 | ||
*[[3bkc]] : WO2 Fab Form B | *[[3bkc]] : WO2 Fab Form B | ||
*[[3bkj]] : WO2 Fab: | *[[3bkj]] : WO2 Fab:Aβ(1-16) complex | ||
*[[3bae]] : WO2 Fab: | *[[3bae]] : WO2 Fab:Aβ(1-28) complex | ||
==Contributors== | ==Contributors== | ||
