Sandbox Reserved 954: Difference between revisions

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==Structure==

== ~~Utility~~ as a tumor marker ==

== The SCCA1 a tumor marker ==

Cancer is characterize as the abnormal proliferation of a cellular clone it will conduce to form a tumor in tissue. Tumoral cells can migrate from the blood or lymph and invade other tissue. Cancer is caused by damaged genes. The cancer can have several origins exogenous factors (cigarettes, alcohol, UV) or endogenous factors (failure DNA repair).

Tumor markers are substances present in abnormal concentration in blood or urine in patients who develop a malignant tumor. Nevertheless tumor markers can appear in people who don’t suffer from cancer or be low for sick patients, this is the false negative or false positive. Tumor markers are used to detect, prevent, diagnose, predict, determine, prognostic and therapeutic monitoring. Tumor markers need to be specific and sensible. The dosage of several markers is necessary to establish the success or the fail of treatment.

The SCCA is secreted by the tumor itself, it a marker of mature cells. It is included in the antigen associated to tumor. This molecule possesses monoclonal antibodies obtain by the injection of homogenate tumor in mice. The SCCA is a glycoprotein present in the epithelium and release in the serum during epidermoid cervical cancer but also in epidermoid cancers as lung, mouth, larynx, pharynx and esophagus. The threshold is inferior at 1.5 µg/L.

=SCCA role as a tumor marker=

SCCA is particularly used for cancer of the uterine cervix. The correlation between SCCA concentration and lung tumor was proved. SCCA concentration increase with the presence of epidermoid lung tumor, independently of the differentiation state of the tumor [1]. SCCA is especially used to prognostic and follow the effects of the treatment in the lung cancer as second tumor marker [2]. High concentration of SCCA in the blood suggests the epithelial cells direct serpin activity to blood. This pathway is an active secretory process.

=SCCA and cancer=

SCCA is not specific of one type of cancer. It can be associated to mild bronchopulmonarypathology, mild skin pathology. It doesn’t depend on Tabaco consumption. SCCA is associated to cancer and non malignant kidney pathology. It is dosed par immune-analyzes. Its half-life is 3 days.

-In cervix cancer :

The SCCA augmentation is linked to the tumor weight and state of disease. Nevertheless 40 % of patients suffer from cervix cancer have a high SCCA blood concentration, it is not use for screening. An increase of initial rate can be a sign of disease recurrence or persistence. It allows to follow the treatment efficiency in patients such as chemotherapy, radiotherapy.

-In epidermoid bronchopulmonary cancer :

SCCA is not used for screening, it is more specific

=Interaction=

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@@ Line 11: / Line 11: @@
 ==Structure==
-== Utility as a tumor marker ==
+== The SCCA1 a tumor marker ==
+Cancer is characterize as the abnormal proliferation of a cellular clone it will conduce to form a tumor in tissue. Tumoral cells can migrate from the blood or lymph and invade other tissue. Cancer is caused by damaged genes. The cancer can have several origins exogenous factors (cigarettes, alcohol, UV) or endogenous factors (failure DNA repair).
+Tumor markers are substances present in abnormal concentration in blood or urine in patients who develop a malignant tumor. Nevertheless tumor markers can appear in people who don’t suffer from cancer or be low for sick patients, this is the false negative or false positive. Tumor markers are used to detect, prevent, diagnose, predict, determine, prognostic and therapeutic monitoring. Tumor markers need to be specific and sensible. The dosage of several markers is necessary to establish the success or the fail of treatment.
+The SCCA is secreted by the tumor itself, it a marker of mature cells. It is included in the antigen associated to tumor. This molecule possesses monoclonal antibodies obtain by the injection of homogenate tumor in mice. The SCCA is a glycoprotein present in the epithelium and release in the serum during epidermoid cervical cancer but also in epidermoid cancers as lung, mouth, larynx, pharynx and esophagus. The threshold is inferior at 1.5 µg/L.
+=SCCA role as a tumor marker=
+SCCA is particularly used for cancer of the uterine cervix. The correlation between SCCA concentration and lung tumor was proved. SCCA concentration increase with the presence of epidermoid lung tumor, independently of the differentiation state of the tumor [1]. SCCA is especially used to prognostic and follow the effects of the treatment in the lung cancer as second tumor marker [2]. High concentration of SCCA in the blood suggests the epithelial cells direct serpin activity to blood. This pathway is an active secretory process.
+=SCCA and cancer=
+SCCA is not specific of one type of cancer. It can be associated to  mild bronchopulmonarypathology, mild skin pathology. It doesn’t depend on Tabaco consumption. SCCA is associated to cancer and non malignant kidney pathology. It is dosed par immune-analyzes. Its half-life is 3 days.
+-In cervix cancer :
+The SCCA augmentation is linked to the tumor weight and state of disease. Nevertheless 40 % of patients suffer from cervix cancer have a high SCCA blood concentration, it is not use for screening. An increase of initial rate can be a sign of disease recurrence or persistence. It allows to follow the treatment efficiency in patients such as chemotherapy, radiotherapy.
+-In epidermoid bronchopulmonary cancer :
+SCCA is not used for screening, it is more specific
 =Interaction=