3te3: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Coiled-coil oligomerization domain of the polycystin transient receptor potential channel PKD2L1== | ==Coiled-coil oligomerization domain of the polycystin transient receptor potential channel PKD2L1== | ||
<StructureSection load='3te3' size='340' side='right' caption='[[3te3]], [[Resolution|resolution]] 2.69Å' scene=''> | <StructureSection load='3te3' size='340' side='right' caption='[[3te3]], [[Resolution|resolution]] 2.69Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3te3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3te3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TE3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TE3 FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PKD2L1, PKD2L, PKDL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PKD2L1, PKD2L, PKDL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3te3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3te3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3te3 RCSB], [http://www.ebi.ac.uk/pdbsum/3te3 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3te3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3te3 OCA], [http://pdbe.org/3te3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3te3 RCSB], [http://www.ebi.ac.uk/pdbsum/3te3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3te3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PK2L1_HUMAN PK2L1_HUMAN]] Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.<ref>PMID:10517637</ref> <ref>PMID:19812697</ref> <ref>PMID:23212381</ref> <ref>PMID:24336289</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 14: | Line 17: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3te3" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Molland, K M]] | [[Category: Molland, K M]] | ||
[[Category: Yernool, D A]] | [[Category: Yernool, D A]] | ||
