3wf0: Difference between revisions
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==Crystal structure of human beta-galactosidase in complex with 6S-NBI-DGJ== | ==Crystal structure of human beta-galactosidase in complex with 6S-NBI-DGJ== | ||
<StructureSection load='3wf0' size='340' side='right' caption='[[3wf0]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='3wf0' size='340' side='right' caption='[[3wf0]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ELNR1, GLB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ELNR1, GLB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wf0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wf0 RCSB], [http://www.ebi.ac.uk/pdbsum/3wf0 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wf0 OCA], [http://pdbe.org/3wf0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wf0 RCSB], [http://www.ebi.ac.uk/pdbsum/3wf0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wf0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/BGAL_HUMAN BGAL_HUMAN]] Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.<ref>PMID:8922281</ref> Isoform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.<ref>PMID:8922281</ref> | [[http://www.uniprot.org/uniprot/BGAL_HUMAN BGAL_HUMAN]] Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.<ref>PMID:8922281</ref> Isoform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.<ref>PMID:8922281</ref> | ||
==See Also== | |||
*[[Galactosidase|Galactosidase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
