Sandbox Reserved 970: Difference between revisions
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== Introduction == | == Introduction == | ||
[[Image:51-TheCalciumPump-1eul-membrane.jpg|200px|left|]] | [[Image:51-TheCalciumPump-1eul-membrane.jpg|200px|left|]] | ||
All living organisms depend on P-type ATPase to pump cation across the membrane. They play a fundamental role in their metabolism and physiology. Ca2+ ATPase is a P-type ATPase which transport calcium ions across the membrane against a concentration gradient. These pumps clear cytoplasm of the second messenger, the calcium. It's very important to keep a low concentration of calcium in the cell for a good cell signaling.The hydrolysis of one adenosine triphosphate (ATP) is essential for the functioning of the pump and the transport of one calcium ion. | All living organisms depend on P-type ATPase to pump cation across the membrane. They play a fundamental role in their metabolism and physiology. Ca2+ ATPase is a P-type ATPase which transport calcium ions across the membrane against a concentration gradient. These pumps clear cytoplasm of the second messenger, the calcium. It's very important to keep a low concentration of calcium in the cell for a good cell signaling.The hydrolysis of one adenosine triphosphate (ATP) is essential for the functioning of the pump and the transport of one calcium ion. | ||
<ref name="second"> David Goodsell, 2004 - Calcium pump molecul of the month - PDB, doi: 10.2210/rcsb_pdb/mom_2004_3</ref> | |||
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The calcium ATPase is a protein composed of 1001 aminoacids. | The calcium ATPase is a protein composed of 1001 aminoacids. | ||
The protein is very rich in <scene name='60/604489/Alpha_regions/1'>alpha helices regions</scene>. It contains <scene name='60/604489/10_transmembrane_helices/1'>10 transmembrane alpha helices</scene>, and three of them line a channel that spans the lipid bilayer and that allows calcium to pass through membranes. It also contains too cytoplasmic loops between the | The protein is very rich in <scene name='60/604489/Alpha_regions/1'>alpha helices regions</scene>. The protein contains 47% of helical regions and 16% of beta sheet regions. It contains <scene name='60/604489/10_transmembrane_helices/1'>10 transmembrane alpha helices</scene>, and three of them line a channel that spans the lipid bilayer and that allows calcium to pass through membranes. It also contains too cytoplasmic loops between the transmembrane helices. When the protein isn’t phosphorylated, two of the transmembrane helices are disrupted and form a cavity that can bind two molecules of calcium. | ||
The protein is divided in <scene name='60/604489/The_4_domains_of_the_pump/1'>4 regions</scene>. The <scene name='60/604489/Transmembrane_domain/1'>transmembrane region</scene> of the protein contains the channel that span the lipid bilayer, and the calcium binding cavity. | The protein is divided in <scene name='60/604489/The_4_domains_of_the_pump/1'>4 regions</scene>. The <scene name='60/604489/Transmembrane_domain/1'>transmembrane region</scene> of the protein contains the channel that span the lipid bilayer, and the calcium binding cavity. | ||
