1v5m: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[1v5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V5M OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V5M FirstGlance].

<table><tr><td colspan='2'>[[1v5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V5M OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V5M FirstGlance].

</td></tr><tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">RIKEN cDNA 5730427K19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>

</td></tr><tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">RIKEN cDNA 5730427K19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v5m RCSB], [http://www.ebi.ac.uk/pdbsum/1v5m PDBsum], [http://www.topsan.org/Proteins/RSGI/1v5m TOPSAN]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v5m OCA], [http://pdbe.org/1v5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v5m RCSB], [http://www.ebi.ac.uk/pdbsum/1v5m PDBsum], [http://www.topsan.org/Proteins/RSGI/1v5m TOPSAN]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SH2B2_MOUSE SH2B2_MOUSE]] Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 (By similarity).

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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__TOC__

</StructureSection>

[[Category: ~~Mus musculus~~]]

[[Category: Lk3 transgenic mice]]

[[Category: Inoue, M]]

[[Category: Kigawa, T]]

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 <StructureSection load='1v5m' size='340' side='right' caption='[[1v5m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1v5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V5M FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1v5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V5M FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 5730427K19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 5730427K19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v5m RCSB], [http://www.ebi.ac.uk/pdbsum/1v5m PDBsum], [http://www.topsan.org/Proteins/RSGI/1v5m TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v5m OCA], [http://pdbe.org/1v5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v5m RCSB], [http://www.ebi.ac.uk/pdbsum/1v5m PDBsum], [http://www.topsan.org/Proteins/RSGI/1v5m TOPSAN]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SH2B2_MOUSE SH2B2_MOUSE]] Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 18: / Line 20: @@
 __TOC__
 </StructureSection>
-[[Category: Mus musculus]]
+[[Category: Lk3 transgenic mice]]
 [[Category: Inoue, M]]
 [[Category: Kigawa, T]]