1ug4: Difference between revisions
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<StructureSection load='1ug4' size='340' side='right' caption='[[1ug4]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='1ug4' size='340' side='right' caption='[[1ug4]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ug4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1ug4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chinese_cobra Chinese cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UG4 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ug4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ug4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ug4 RCSB], [http://www.ebi.ac.uk/pdbsum/1ug4 PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ug4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ug4 OCA], [http://pdbe.org/1ug4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ug4 RCSB], [http://www.ebi.ac.uk/pdbsum/1ug4 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/3SAN_NAJAT 3SAN_NAJAT]] Basic protein that bind to cell membrane and depolarizes cardiomyocytes. This cytotoxin also shows lytic activities, on many other cells including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. Inhibits protein kinases C (By similarity). It binds to the integrin alpha-V/beta-3 with a moderate affinity (PubMed:16407244).<ref>PMID:16407244</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1ug4" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Chinese cobra]] | ||
[[Category: Chen, C J]] | [[Category: Chen, C J]] | ||
[[Category: Chung, F Y]] | [[Category: Chung, F Y]] | ||
