Tachyplesin: Difference between revisions
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By binding to DNA and RNA TP-I inhibits the synthesis of macromolecules. | By binding to DNA and RNA TP-I inhibits the synthesis of macromolecules. | ||
In summary, three processes might happen upon TP-I exposure: (1) Bacterial cell membranes are penetrated without disruption of the membrane and the peptide reaches the inner structures of the cell, damaging critical intracellular targets and interfering with intracellular functions and normal metabolism. (2) Pores are formed in the cell wall, causing leakage of intracellular content, leading to cell death. (3) DNA, RNA or protein synthesis are inhibited, killing the bacteria.<ref name=Hong>Hong, Jun, et al. "Mechanism of tachyplesin I injury to bacterial membranes and intracellular enzymes, determined by laser confocal scanning microscopy and flow cytometry." Microbiological research (2014).</ref> | |||
== Importance and relevance == | == Importance and relevance == | ||
