Sandbox Reserved 970: Difference between revisions
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[[Image:51-TheCalciumPumps-calcium-pumps.jpg|400px|center|]] | [[Image:51-TheCalciumPumps-calcium-pumps.jpg|400px|center|]] | ||
The structure on the left is the | The structure on the left is the empty state (free from calcium). Two calcium ions are show in blue and Asp351 is show in red.<ref name="second"> David Goodsell, 2004 - Calcium pump molecul of the month - PDB, doi: 10.2210/rcsb_pdb/mom_2004_3</ref> | ||
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Another example of regulation. The plasma membrane calcium pump carboxy-terminal tail contains the calmodulin binding domain (regulatory domain) which acts as an auto-inhibitory domain. The binding of the calmodulin frees the pump from autoinhibition<ref>Marisa Brini and Ernesto Carafoli, 2010 - ''The plasma membrane Ca2+ ATPase and the Plasma Membrane Sodium Calcium Exchanger Cooperate in the Regulation of Cell Calcium'' - Cold Spring Harbor Perspectives in Biology, http://cshperspectives.cshlp.org/content/3/2/a004168.full</ref>. | Another example of regulation. The plasma membrane calcium pump carboxy-terminal tail contains the calmodulin binding domain (regulatory domain) which acts as an auto-inhibitory domain. The binding of the calmodulin frees the pump from autoinhibition<ref>Marisa Brini and Ernesto Carafoli, 2010 - ''The plasma membrane Ca2+ ATPase and the Plasma Membrane Sodium Calcium Exchanger Cooperate in the Regulation of Cell Calcium'' - Cold Spring Harbor Perspectives in Biology, http://cshperspectives.cshlp.org/content/3/2/a004168.full</ref>. | ||
<scene name='60/604489/E2_state_free_3w5c/2'>ecrire ici</scene> E2 state free from calcium | |||
== Dysfunctions and Diseases == | == Dysfunctions and Diseases == | ||
