Sandbox Reserved 970: Difference between revisions

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All living organisms depend on P-type ATPase to pump cation across the membrane. P-type ATPases are distinct from other ATPases because there is an autophosphorylation step in the catalytic cycle.  They play a fundamental role in organisms metabolism and physiology.  
All living organisms depend on P-type ATPase to pump cation across the membrane. P-type ATPases are distinct from other ATPases because there is an autophosphorylation step in the catalytic cycle.  They play a fundamental role in organisms metabolism and physiology.  
Ca2+ ATPase are P-type ATPase which transport calcium ions across the membrane against a concentration gradient. These pumps clear cytoplasm of the second messenger, the calcium. It's very important to keep a low concentration of calcium in the cell for a good cell signaling. The hydrolysis of ATP is necessary for the pump's functioning. For each ATP hydrolysed, it transfers two calcium ions through the membrane, and two or three hydrogen ions in the opposite direction.
Ca2+ ATPase are P-type ATPase which transport calcium ions across the membrane against a concentration gradient. These pumps clear cytoplasm of the second messenger, the calcium. It's very important to keep a low concentration of calcium in the cell for a good cell signaling. The hydrolysis of ATP is necessary for the pump's functioning. For each ATP hydrolysed, it transfers two calcium ions through the membrane, and two or three hydrogen ions in the opposite direction.
<ref name="second"> David Goodsell, 2004 - ''Calcium pump molecul of the month'' - PDB, doi: 10.2210/rcsb_pdb/mom_2004_3</ref>
 


== Structural Highlights ==
== Structural Highlights ==
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[[Image:51-TheCalciumPumps-calcium-pumps.jpg|400px|center|]]
[[Image:51-TheCalciumPumps-calcium-pumps.jpg|400px|center|]]
The structure on the left is the empty state (free from calcium). Two calcium ions are show in blue and Asp351 is show in red.<ref name="second"> David Goodsell, 2004 - Calcium pump molecul of the month - PDB, doi: 10.2210/rcsb_pdb/mom_2004_3</ref>
The structure on the left is the empty state (free from calcium). Two calcium ions are show in blue and Asp351 is show in red<ref> David Goodsell, 2004 - ''Calcium pump molecul of the month'' - PDB, doi: 10.2210/rcsb_pdb/mom_2004_3</ref>.




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