Sandbox Reserved 954: Difference between revisions

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==Introduction==

Squamous cell carcinoma antigen is a tumor associated protein of squamous cell carcinoma of various organs. SCCA was originally purified from SCC of the uterine cervix <ref>Martz, E. Book review of ''Introduction to protein science—architecture, function, and genomics: Lesk, Arthur M. Biochem. Mol. Biol. Educ.'' 33:144-5 (2006). [http://link.springer.com/chapter/10.1007/978-1-4612-0401-5_21#page-1 DOI :10.1007/978-1-4612-0401-5_21#page-1]</ref>. SCCA is a [http://en.wikipedia.org/wiki/Tumor_marker tumor marker] to detect malignant tumor and to understand biological behaviors of squamous cells. SCCA is classified as a serine protease inhibitor called [http://en.wikipedia.org/wiki/Serpin serpin] B3. It also inhibits [http://en.wikipedia.org/wiki/Chymotrypsin chymotripsin], [http://en.wikipedia.org/wiki/Cathepsin cathepsin] L, K and S and papain like cysteine proteases. In the case of tumor development SCCA 1 inhibits NK cells(natural killer), TNFalfa and apoptosis of tumor cells induced by treatment. It can also play a role in tumor growth. The chromosomal location is the locus 18q21.3.<ref>PMID:9817978</ref>

</StructureSection>

~~Anything~~ in ~~this section will appear adjacent~~ to the ~~3D structure~~ and ~~will be scrollable~~.

==General structure==

Serpins are a superfamily of functionally distinct but structurally conserved proteins. <ref>JBC Papers in Press. Published on July 2, 2001 as Manuscript R100016200 THE SERPINS ARE AN EXPANDING SUPERFAMILY OF

STRUCTURALLY SIMILAR BUT FUNCTIONALLY DIVERSE PROTEINShttp://www.jbc.org/content/early/2001/07/02/jbc.R100016200.full.pdf DOI : 2001/07/02/jbc.R100016200.full.pdf </ref>

SerpinB3 means serin protease inhibitor, clade B (ovalbumin), member 3. The particularity of Serpin B3 is to target proteases wich have a nucleophilic cysteine instead of serine in their catalytic site.

SCCA1 is a <scene name='60/604473/Trimeric/1'>trimeric protein</scene><ref> PMID : 19166818 </ref>

. Like all for serpins, <scene name='60/604473/One_subunit/1'>one subunit</scene> has three β sheets termed <scene name='60/604473/A_beta_sheet/3'>A (7 stranded)</scene>, <scene name='60/604473/B_beta_sheet/2'>B (5 stranded)</scene> and <scene name='60/604473/C_beta_sheet/2'>C (6 stranded)</scene> and <scene name='60/604473/Alpha_helices/1'>11 α helices (hA to hK)</scene> <ref>Gary A. Silverman1*, Phillip I. Bird2

, Robin W. Carrell3

, Frank C. Church4

, Paul B. Coughlin5

, Peter G.W. Gettins6

,

James A Irving2

, David A. Lomas3

, Cliff J. Luke1

, Richard W. Moyer7

, Philip A. Pemberton8

, Eileen RemoldO'Donnell9

, Guy S. Salvesen10, James Travis11 and James C. Whisstock, THE SERPINS ARE AN EXPANDING SUPERFAMILY OF

STRUCTURALLY SIMILAR BUT FUNCTIONALLY DIVERSE PROTEINS, http://www.jbc.org/content/early/2001/07/02/jbc.R100016200.full.pdf DOI : 2001/07/02/jbc.R100016200.full.pdf </ref> <ref>PDB, Crystal structure of human squamous cell carcinoma antigen 1 http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=2ZV6&bionumber=1 DOI : pdb/explore/remediatedSequence.do?structureId=2ZV6&bionumber=1</ref> .

The most important part of Serpins is an exposed region of 20 amino acids near the C terminus named the reactive center loop (<scene name='60/604473/The_rcl_loop_scene/3'>RCL</scene>). The amino-acids of <scene name='60/604473/The_rcl_loop_scene/3'>RCL</scene> are very conservated for Serpin B3 and allow the specificity interaction of the inhibitor for the target protease<ref> PMID : PMC24842</ref>.

Sandbox Reserved 954: Difference between revisions

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@@ Line 6: / Line 6: @@
 ==Introduction==
 Squamous cell carcinoma antigen is a tumor associated protein of squamous cell carcinoma of various organs. SCCA was originally purified from SCC of the uterine cervix <ref>Martz, E. Book review of ''Introduction to protein science—architecture, function, and genomics: Lesk, Arthur M. Biochem. Mol. Biol. Educ.'' 33:144-5 (2006). [http://link.springer.com/chapter/10.1007/978-1-4612-0401-5_21#page-1 DOI :10.1007/978-1-4612-0401-5_21#page-1]</ref>. SCCA is a [http://en.wikipedia.org/wiki/Tumor_marker tumor marker] to detect malignant tumor and to understand biological behaviors of squamous cells. SCCA is classified as a serine protease inhibitor called [http://en.wikipedia.org/wiki/Serpin serpin] B3. It also inhibits [http://en.wikipedia.org/wiki/Chymotrypsin chymotripsin], [http://en.wikipedia.org/wiki/Cathepsin cathepsin] L, K and S and papain like cysteine proteases. In the case of tumor development SCCA 1 inhibits NK cells(natural killer), TNFalfa and apoptosis of tumor cells induced by treatment. It can also play a role in tumor growth. The chromosomal location is the locus 18q21.3.<ref>PMID:9817978</ref>
 </StructureSection>
-Anything in this section will appear adjacent to the 3D structure and will be scrollable.
+==General structure==
+Serpins are a superfamily of functionally distinct but structurally conserved proteins. <ref>JBC Papers in Press. Published on July 2, 2001 as Manuscript R100016200 THE SERPINS ARE AN EXPANDING SUPERFAMILY OF
+STRUCTURALLY SIMILAR BUT FUNCTIONALLY DIVERSE PROTEINShttp://www.jbc.org/content/early/2001/07/02/jbc.R100016200.full.pdf DOI : 2001/07/02/jbc.R100016200.full.pdf </ref>
+SerpinB3 means serin protease inhibitor, clade B (ovalbumin), member 3. The particularity of Serpin B3 is to target proteases wich have a nucleophilic cysteine instead of serine in their catalytic site.
+SCCA1 is a <scene name='60/604473/Trimeric/1'>trimeric protein</scene><ref> PMID : 19166818 </ref>
+. Like all for serpins, <scene name='60/604473/One_subunit/1'>one subunit</scene> has three β sheets termed <scene name='60/604473/A_beta_sheet/3'>A (7 stranded)</scene>, <scene name='60/604473/B_beta_sheet/2'>B (5 stranded)</scene> and <scene name='60/604473/C_beta_sheet/2'>C (6 stranded)</scene> and <scene name='60/604473/Alpha_helices/1'>11  α helices (hA to hK)</scene> <ref>Gary A. Silverman1*, Phillip I. Bird2
+, Robin W. Carrell3
+, Frank C. Church4
+, Paul B. Coughlin5
+, Peter G.W. Gettins6
+,
+James A Irving2
+, David A. Lomas3
+, Cliff J. Luke1
+, Richard W. Moyer7
+, Philip A. Pemberton8
+, Eileen RemoldO'Donnell9
+, Guy S. Salvesen10, James Travis11 and James C. Whisstock, THE SERPINS ARE AN EXPANDING SUPERFAMILY OF
+STRUCTURALLY SIMILAR BUT FUNCTIONALLY DIVERSE PROTEINS, http://www.jbc.org/content/early/2001/07/02/jbc.R100016200.full.pdf DOI : 2001/07/02/jbc.R100016200.full.pdf </ref> <ref>PDB, Crystal structure of human squamous cell carcinoma antigen 1 http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=2ZV6&bionumber=1 DOI : pdb/explore/remediatedSequence.do?structureId=2ZV6&bionumber=1</ref> .
+The most important part of Serpins is an exposed region of 20 amino acids near the C terminus named the reactive center loop (<scene name='60/604473/The_rcl_loop_scene/3'>RCL</scene>). The amino-acids of <scene name='60/604473/The_rcl_loop_scene/3'>RCL</scene> are very conservated for Serpin B3 and  allow the specificity interaction of the inhibitor for the target protease<ref> PMID : PMC24842</ref>.