Sandbox Reserved 954: Difference between revisions
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Léo Alcapia (talk | contribs) No edit summary |
Léo Alcapia (talk | contribs) No edit summary |
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Moreover, a mutant protein created by replacing <scene name='60/604473/Phe_352/1'>one amino-acid</scene> in <scene name='60/604473/The_rcl_loop_scene/3'>RCL</scene> even retains the suppressive activity against JNK1 but the inhibitory proteinase activity is reduced. | Moreover, a mutant protein created by replacing <scene name='60/604473/Phe_352/1'>one amino-acid</scene> in <scene name='60/604473/The_rcl_loop_scene/3'>RCL</scene> even retains the suppressive activity against JNK1 but the inhibitory proteinase activity is reduced. | ||
<ref> PMID : 19166818<ref> | <ref> PMID : 19166818<ref> | ||
This | This indicates that exposed <scene name='60/604473/The_rcl_loop_scene/3'>RCL</scene> is essential for the JNK1 inhibitory activity and that JNK1 interaction site is different from the protease site. Actually, JNK1 may binds the <scene name='60/604473/The_rcl_loop_scene/3'>RCL</scene> region, excepting the protease binding site, or the center of <scene name='60/604473/A_beta_sheet/3'>A β-sheet</scene>. | ||
===Receptor (LPR) interaction=== | ===Receptor (LPR) interaction=== | ||
