Sandbox Reserved 967: Difference between revisions
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There are two types of RNase H (RNases H1 and RNases H2) classified according to their sequence conservation and substrate preference. Currently, three types of RNA/DNA hybrids are known: simple RNA/DNA duplexes ('''Figure 1A'''), RNA•DNA/DNA hybrids ('''Figure 1B'''), and DNA•RNAfew•DNA/DNA hybrids ('''Figure 1C'''). RNases H2 is totally able to cleave a single ribonucleotide embedded in a double strand DNA (DNA• RNAfew •DNA/DNA type) when RNases H1 require at least 4 ribonucleotides. This ability and their high expression in proliferating cells suggest that RNases H2 are involved in DNA repair and replication. | There are two types of RNase H (RNases H1 and RNases H2) classified according to their sequence conservation and substrate preference. Currently, three types of RNA/DNA hybrids are known: simple RNA/DNA duplexes ('''Figure 1A'''), RNA•DNA/DNA hybrids ('''Figure 1B'''), and DNA•RNAfew•DNA/DNA hybrids ('''Figure 1C'''). RNases H2 is totally able to cleave a single ribonucleotide embedded in a double strand DNA (DNA• RNAfew •DNA/DNA type) when RNases H1 require at least 4 ribonucleotides. This ability and their high expression in proliferating cells suggest that RNases H2 are involved in DNA repair and replication. | ||
[[Image: | [[Image:ThreetypesofRNA-DNAhybrids.png|300px|left|thumb| '''Figure 1''' : Three types of RNA/DNA hybrids]] | ||
''Manque figure, à ajouter...'' | ''Manque figure, à ajouter...'' | ||
