Sandbox Reserved 971: Difference between revisions
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== Introduction == | == Introduction == | ||
Interleukin 33 is a cytokine member of the | [http://www.ncbi.nlm.nih.gov/gene/90865 Interleukin 33] is a cytokine member of the [http://www.ncbi.nlm.nih.gov/pubmed/24677376 interleukin 1 superfamily]. Cytokines are proteins involved in cell signaling. Their role is to regulate the function and the activity of other cells. IL-33 is involved in innate and adaptive immune responses. | ||
In 2005, IL-33 was identified as a ligand for the transmembrane receptor ST2 and it IL-1 receptor accessory protein (IL-1RAcP), both members of the interleukin-1 receptor family. IL-33/ST2 signaling is involved in T-cell immune responses. | In 2005, IL-33 was identified as a ligand for the transmembrane receptor ST2 (also known as [http://www.ncbi.nlm.nih.gov/gene/9173 IL1RL1] and it IL-1 receptor accessory protein (IL-1RAcP), both members of the [http://www.ncbi.nlm.nih.gov/pubmed/17027517 interleukin-1 receptor family]. IL-33/ST2 signaling is involved in T-cell immune responses. | ||
We will focuse on the interaction bewteen IL33 and the ST2 ectodomain (as you can see <scene name='61/614056/Name_il33_st2/1'>here</scene>). | We will focuse on the interaction bewteen IL33 and the ST2 ectodomain (as you can see <scene name='61/614056/Name_il33_st2/1'>here</scene>). | ||
