Sandbox Reserved 951: Difference between revisions
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== Global Structure == | |||
Luciferase is a 62kDa protein. It contains 550 amino acids. The enzyme can be divide into two domains. On the one hand, the major portion, corresponding to the N-terminal. It has an antiparallel β barrel, 2 β sheets, which are framed by α helices. On the other hand, the small portion, corresponding to the C-terminal. It has α + β structure. Those two domains are separated by a large cleft. | |||
The amino acids of C terminal sequence is composed of contiguous residues, whereas they are three subdomains (noted A, B, and C) in the N terminal domain which are not contigous. | |||
Each of the two β sheets subdomains (A and B) in the N terminal domain are composed of 8 β strands and 6 helices. The β sheet A has 5 parallel and 3 antiparallel β strands. The β sheet B has 6 parallel and 2 antiparallel β strands. Those β sheets create a groove, closed on one end by the β barrel. | |||
The C terminal form a type of lid upon the N terminal domain. It contains two β sheets: one is composed of two short antiparallel strands and the other one is composed of 3 antiparallel strands, mixed with 3 α helices. Those helices are put toward the outside. | |||
== Structure related to functions == | == Structure related to functions == | ||
