Sandbox Reserved 971: Difference between revisions
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[http://www.ncbi.nlm.nih.gov/gene/90865 Interleukin 33] is a cytokine member of the [http://www.ncbi.nlm.nih.gov/pubmed/24677376 interleukin 1 superfamily]. Cytokines are proteins involved in cell signaling. Their role is to regulate the function and the activity of other cells. IL-33 is involved in innate and adaptive immune responses. | [http://www.ncbi.nlm.nih.gov/gene/90865 Interleukin 33] is a cytokine member of the [http://www.ncbi.nlm.nih.gov/pubmed/24677376 interleukin 1 superfamily]. Cytokines are proteins involved in cell signaling. Their role is to regulate the function and the activity of other cells. IL-33 is involved in innate and adaptive immune responses. | ||
In 2005, IL-33 was identified as a ligand for the transmembrane receptor ST2 (also known as [http://www.ncbi.nlm.nih.gov/gene/9173 IL1RL1] and it IL-1 receptor accessory protein (IL-1RAcP), both members of the [http://www.ncbi.nlm.nih.gov/pubmed/17027517 interleukin-1 receptor family]. IL-33/ST2 signaling is involved in T-cell immune responses. | In 2005, IL-33 was identified as a ligand for the transmembrane receptor ST2 (also known as [http://www.ncbi.nlm.nih.gov/gene/9173 IL1RL1] and it IL-1 receptor accessory protein (IL-1RAcP) as you see below, both members of the [http://www.ncbi.nlm.nih.gov/pubmed/17027517 interleukin-1 receptor family]. IL-33/ST2 signaling is involved in T-cell immune responses. | ||
[[Image:IL33_with_its_receptor.png]] | [[Image:IL33_with_its_receptor.png]] | ||
