Sandbox Reserved 962: Difference between revisions
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The mRNA Cap (Guanine-N7) Methyltransferase is an enzyme which catalyses the reaction of capping the C-terminal domain of a mRNA with a m7G(5')pppR cap. | The mRNA Cap (Guanine-N7) Methyltransferase is an enzyme which catalyses the reaction of capping the C-terminal domain of a mRNA with a m7G(5')pppR cap. | ||
It has been the least understood enzyme intervening in capping. To be studied, the cap methyltransferase has been isolated on purified vaccinia virus by Martin and Moss in 1975-1976. | |||
<Structure load='1ri1' size='350' frame='true' align='right' caption='Ecm1' scene='60/604481/Scene_depart/3' /> | <Structure load='1ri1' size='350' frame='true' align='right' caption='Ecm1' scene='60/604481/Scene_depart/3' /> | ||
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One of the enzymes catalysing this reaction is the mRNA Cap (Guanine-N7) Methyltransferase. | One of the enzymes catalysing this reaction is the mRNA Cap (Guanine-N7) Methyltransferase. | ||
The cap allows the mRNA to be recognized by a protein complex which is involved in traduction initiation. | The cap allows the mRNA to be recognized by a protein complex which is involved in traduction initiation. It is also necessary to keep the stability of the ARN. | ||
== Structure == | == Structure == | ||
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The structure of ECM1 (the smallest cap methyltranferase identified) is similar to the structure of the whole family of cap methyltransferase. | The structure of ECM1 (the smallest cap methyltranferase identified) is similar to the structure of the whole family of cap methyltransferase. | ||
We can indentify structural repeatings characteristic | We can indentify structural repeatings characteristic of the family : amongst others alpha helices or bêta-sheets can be found. | ||
The structure of the protein could be divided in two segments : | The structure of the protein could be divided in two segments : | ||
