Sandbox Reserved 973: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Léa Barbin (talk | contribs) No edit summary |
Léa Barbin (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<Structure load='4F3L' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='4F3L' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
== CLOCK:BMAL1 heterodimer | |||
==CLOCK:BMAL1 heterodimer | |||
Function and overall structure == | |||
The pacemaker of the circadian system is the suprachiamastic nucleus (SNC) located in the hypothalamus. This center controls the circadian rhythm through the coordination of peripheric oscillators all over the organism. The mechanisms that occur in the peripheric system are, at a molecular level, very similar to those in the SNC; that is to say a network of transcriptional and translational regulations, creating different loops that take about 24 hours to complete. This circadian cycle regulates many physiologic parameters and coordonates several phenomenon such as sleep period or hormon levels. One of the most important proteins in this rhythm is the heterodimeric complex CLOCK:BMAL1, which is a transcriptionnal factor responsible for the activation of 2 type of genes; Period(Per1,Per2) and Cryptochrome(Cry1,Cry2), by interacting with the E-box DNA. Indeed mutants mice devoid of CLOCK or BMAL1 proteins have seriously disrupted rhythm, at a molecular level as well as on their behavior. | The pacemaker of the circadian system is the suprachiamastic nucleus (SNC) located in the hypothalamus. This center controls the circadian rhythm through the coordination of peripheric oscillators all over the organism. The mechanisms that occur in the peripheric system are, at a molecular level, very similar to those in the SNC; that is to say a network of transcriptional and translational regulations, creating different loops that take about 24 hours to complete. This circadian cycle regulates many physiologic parameters and coordonates several phenomenon such as sleep period or hormon levels. One of the most important proteins in this rhythm is the heterodimeric complex CLOCK:BMAL1, which is a transcriptionnal factor responsible for the activation of 2 type of genes; Period(Per1,Per2) and Cryptochrome(Cry1,Cry2), by interacting with the E-box DNA. Indeed mutants mice devoid of CLOCK or BMAL1 proteins have seriously disrupted rhythm, at a molecular level as well as on their behavior. | ||
