Sandbox Reserved 966: Difference between revisions
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=== Structural highlights === | === Structural highlights === | ||
== Mechanism == | == Mechanism == | ||
The neurotoxin inactivates neurotransmitter release owing to its metalloprotease activity. It targets the presynaptic membrane of peripheral nerve terminals using a binding mode based on the use of two independent receptors: a polysialoganglioside (PSG) and a protein receptor in the lumen of synaptic vesicles<ref>PMID: 23239349</ref>. ''Clostridium botulinum'' neurotoxin is initially synthesized as a single polypeptide chain of ≈150 kDa and is then cleaved by a protease to yield the mature toxin, which consists of a light chain (LC which is 50 kDa) and a heavy chain (HC which is 100 kDa). The heavy chain presents the | |||
[[Image:Mecanismefinal.jpg|thumb|'''Figure 2 :''' Enzymatic mechanism (made using ChemDraw Ultra by Xavier Hartmann ]] | [[Image:Mecanismefinal.jpg|thumb|'''Figure 2 :''' Enzymatic mechanism (made using ChemDraw Ultra by Xavier Hartmann ]] | ||
<scene name='60/604485/Catalytic_site/2'>Catalytic site</scene> | <scene name='60/604485/Catalytic_site/2'>Catalytic site</scene> | ||
