2jbj: Difference between revisions
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|PDB= 2jbj |SIZE=350|CAPTION= <scene name='initialview01'>2jbj</scene>, resolution 2.19Å | |PDB= 2jbj |SIZE=350|CAPTION= <scene name='initialview01'>2jbj</scene>, resolution 2.19Å | ||
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Ca+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Cl+Binding+Site+For+Chain+A'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Chain+A'>AC6</scene>, <scene name='pdbsite=AC7:Nag+Binding+Site+For+Chain+A'>AC7</scene>, <scene name='pdbsite=AC8:Nag+Binding+Site+For+Chain+A'>AC8</scene>, <scene name='pdbsite=BC1:Nag+Binding+Site+For+Chain+A'>BC1</scene>, <scene name='pdbsite=BC2:Nag+Binding+Site+For+Chain+A'>BC2</scene>, <scene name='pdbsite=BC3:Nag+Binding+Site+For+Chain+A'>BC3</scene>, <scene name='pdbsite=BC4:Nag+Binding+Site+For+Chain+A'>BC4</scene>, <scene name='pdbsite=BC5:Nag+Binding+Site+For+Chain+A'>BC5</scene>, <scene name='pdbsite=BC6:Nag+Binding+Site+For+Chain+A'>BC6</scene>, <scene name='pdbsite=BC7:Bma+Binding+Site+For+Chain+A'>BC7</scene>, <scene name='pdbsite=BC8:Man+Binding+Site+For+Chain+A'>BC8</scene> and <scene name='pdbsite=BC9:G88+Binding+Site+For+Chain+A'>BC9</scene> | |SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Ca+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Cl+Binding+Site+For+Chain+A'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Chain+A'>AC6</scene>, <scene name='pdbsite=AC7:Nag+Binding+Site+For+Chain+A'>AC7</scene>, <scene name='pdbsite=AC8:Nag+Binding+Site+For+Chain+A'>AC8</scene>, <scene name='pdbsite=BC1:Nag+Binding+Site+For+Chain+A'>BC1</scene>, <scene name='pdbsite=BC2:Nag+Binding+Site+For+Chain+A'>BC2</scene>, <scene name='pdbsite=BC3:Nag+Binding+Site+For+Chain+A'>BC3</scene>, <scene name='pdbsite=BC4:Nag+Binding+Site+For+Chain+A'>BC4</scene>, <scene name='pdbsite=BC5:Nag+Binding+Site+For+Chain+A'>BC5</scene>, <scene name='pdbsite=BC6:Nag+Binding+Site+For+Chain+A'>BC6</scene>, <scene name='pdbsite=BC7:Bma+Binding+Site+For+Chain+A'>BC7</scene>, <scene name='pdbsite=BC8:Man+Binding+Site+For+Chain+A'>BC8</scene> and <scene name='pdbsite=BC9:G88+Binding+Site+For+Chain+A'>BC9</scene> | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G88:(2S)-2-(PHOSPHONOMETHYL)PENTANEDIOIC+ACID'>G88</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Glutamate_carboxypeptidase_II Glutamate carboxypeptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.21 3.4.17.21] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_carboxypeptidase_II Glutamate carboxypeptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.21 3.4.17.21] </span> | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1z8l|1Z8L]], [[2c6c|2C6C]], [[2c6g|2C6G]], [[2c6p|2C6P]], [[2cij|2CIJ]], [[2jbk|2JBK]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbj OCA], [http://www.ebi.ac.uk/pdbsum/2jbj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jbj RCSB]</span> | |||
}} | }} | ||
| Line 14: | Line 17: | ||
==Overview== | ==Overview== | ||
Human glutamate carboxypeptidase II (GCPII) occurs in the central nervous system as well as in human prostate (where it is called prostate-specific membrane antigen; PSMA). Inhibitors of the enzyme have been shown to provide neuroprotection, but may also be useful for the detection, imaging and treatment of prostate cancer. Crystal structures were determined of the extracellular part of GCPII (amino-acid residues 44-750) in complex with two potent inhibitors, quisqualate and 2-PMPA (the strongest GCPII inhibitor to date), at resolutions of 3.0 and 2.2 A, respectively. In addition, models were constructed for binding of the inhibitors willardiine, homoibotenate, L-2-amino-4-phosphonobutanoic acid and L-serine-O-sulfate to the S1' site of the enzyme. The common denominator for high-affinity binding to the S1' site is the formation of two strong salt bridges. | Human glutamate carboxypeptidase II (GCPII) occurs in the central nervous system as well as in human prostate (where it is called prostate-specific membrane antigen; PSMA). Inhibitors of the enzyme have been shown to provide neuroprotection, but may also be useful for the detection, imaging and treatment of prostate cancer. Crystal structures were determined of the extracellular part of GCPII (amino-acid residues 44-750) in complex with two potent inhibitors, quisqualate and 2-PMPA (the strongest GCPII inhibitor to date), at resolutions of 3.0 and 2.2 A, respectively. In addition, models were constructed for binding of the inhibitors willardiine, homoibotenate, L-2-amino-4-phosphonobutanoic acid and L-serine-O-sulfate to the S1' site of the enzyme. The common denominator for high-affinity binding to the S1' site is the formation of two strong salt bridges. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Hilgenfeld, R.]] | [[Category: Hilgenfeld, R.]] | ||
[[Category: Mesters, J R.]] | [[Category: Mesters, J R.]] | ||
[[Category: alternative splicin]] | [[Category: alternative splicin]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
| Line 57: | Line 52: | ||
[[Category: zinc]] | [[Category: zinc]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:55:46 2008'' | ||
