4s0n: Difference between revisions

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'''~~Unreleased structure~~'''

==Crystal Structure of HLTF HIRAN Domain bound to DNA==

~~The entry~~ 4s0n is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4s0n]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S0N FirstGlance]. <br>

~~Authors~~: ~~Chavez~~, D.A., ~~Eichman~~, B.F.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s0n RCSB], [http://www.ebi.ac.uk/pdbsum/4s0n PDBsum]</span></td></tr>

~~Description~~: ~~Crystal Structure~~ of ~~HLTF HIRAN Domain bound~~ to DNA

</table>

[[Category: ~~Unreleased Structures~~]]

== Function ==

[[Category: Eichman, B.F]]

[[http://www.uniprot.org/uniprot/HLTF_HUMAN HLTF_HUMAN]] Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.<ref>PMID:10391891</ref> <ref>PMID:18316726</ref> <ref>PMID:18719106</ref> <ref>PMID:7876228</ref> <ref>PMID:8672239</ref> <ref>PMID:9126292</ref>

[[Category: ~~Chavez, D.A~~]]

== References ==

__TOC__

</StructureSection>

[[Category: Chavez, D A]]

[[Category: Eichman, B F]]

[[Category: Alpha+beta]]

[[Category: Dna 3'-end binding]]

[[Category: Dna binding protein-dna complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal Structure of HLTF HIRAN Domain bound to DNA==
+<StructureSection load='4s0n' size='340' side='right' caption='[[4s0n]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-The entry 4s0n is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4s0n]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S0N FirstGlance]. <br>
-Authors: Chavez, D.A., Eichman, B.F.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s0n RCSB], [http://www.ebi.ac.uk/pdbsum/4s0n PDBsum]</span></td></tr>
-Description: Crystal Structure of HLTF HIRAN Domain bound to DNA
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
-[[Category: Eichman, B.F]]
+[[http://www.uniprot.org/uniprot/HLTF_HUMAN HLTF_HUMAN]] Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.<ref>PMID:10391891</ref> <ref>PMID:18316726</ref> <ref>PMID:18719106</ref> <ref>PMID:7876228</ref> <ref>PMID:8672239</ref> <ref>PMID:9126292</ref>
-[[Category: Chavez, D.A]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Chavez, D A]]
+[[Category: Eichman, B F]]
+[[Category: Alpha+beta]]
+[[Category: Dna 3'-end binding]]
+[[Category: Dna binding protein-dna complex]]